Asthma?

New study treatments that may put you back in control.

The respiratory condition that can make breathing difficult has several options on the market. But for those who still struggle with attacks, we’re working on giving you new options. Learn about the cutting-edge study treatments being investigated near you.

of Americans
have been diagnosed with severe Asthma. ¹

1.5

million people
use an inhaler everyday

100s

of treatments on the market
None of them a pill that stop attacks

I wish there was something else like a pill that you take once a week or per month to help with airwaves and breathing so I didn’t have to take the inhaler everywhere. That would be nice.

Patient

7 years with Asthma

I take my inhaler with me everywhere, I’m a control freak. My backpack always has water, cliff bar, allergy meds, and of course my inhaler is always in there too.

Patient

21 years with Asthma

Asthma Clinical Trials

Learn about the newest Asthma study treatments now being investigated, including cutting-edge options available to clinical trial participants.

TrialSpark is now recruiting for a trial that tests the effectiveness of a study drug for Asthma symptoms.

Learn more

A new asthma drug candidate called fevipiprant

The overall purpose of this study is to determine the efficacy of fevipiprant (dose 1 and dose 2 once daily), compared with placebo, as add-on to standard-of-care asthma therapy, in terms of avoidance of...

Compensation

N/A

Trial Type

Interventional

Sponsorship

Novartis

Clinicaltrials.gov

Technology Enabled Asthma Management System (TEAMS) Pilot Study

To evaluate feasibility, acceptability, safety, and preliminary efficacy of a novel patient-centered, technology-based intervention to improve asthma care in younger adult smartphone users. The program, called...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

University of Rhode Island

Clinicaltrials.gov

Pediatric ASTHMA-Educator

This project seeks to develop and pilot test the pediatric ASTHMA-Educator mobile application.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Montefiore Medical Center

Clinicaltrials.gov

Observational Study of Characteristics, Treatment and Outcomes With...

The CHRONICLE Study is a multi-center, non-interventional, prospective cohort study of adults with severe asthma who do not achieve control with high-dose inhaled corticosteroid (ICS) therapy with additional...

Trial Type

Observational [Patient Registry]

Sponsorship

MedImmune LLC

Clinicaltrials.gov

BE Study of Fluticasone Propionate/Salmeterol Inhalation Powder in...

The purpose of this study is to demonstrate the pharmacodynamic bioequivalence of the test product to the reference product in adult patients with asthma.

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

Cipla Ltd.

Clinicaltrials.gov

Pneumococcal Vaccines in Patients With Asthma

Investigators are assessing if patients with asthma respond better to the Pneumovax vaccine if they are given Prevnar initially.

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

Mayo Clinic

Clinicaltrials.gov

Biomarkers of Irritant-Induced and Allergic Asthma

Asthma is a heterogeneous disease, and although much is understood about mechanisms of inflammation in allergic asthma, less is known about mechanisms of irritant-induced asthma (IA). Understanding the...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

New York University School of Medicine

Clinicaltrials.gov

Airway Temperature

Airway irritation, cough and bronchial spasm are common symptoms in patients with airway inflammatory diseases such as asthma. The primary focus of this exploratory study is to determine if there is an...

Trial Type

Interventional

Trial Phase

Phase 1

Sponsorship

National Institute of Allergy and Infectious Diseases (NIAID)

Clinicaltrials.gov

Indoor Air Pollution and Children With Asthma: An Intervention Trial

The purpose of this study is to determine whether reducing indoor exposure to NO2 and particles improves respiratory health in children with asthma.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Institute of Environmental Health Sciences (NIEHS)

Clinicaltrials.gov

Upper Airway Microbial Development During the First Year of Life

This study tests the hypothesis that an increase in pathogenic bacteria within the infant airway leads to increased airway inflammation, decreased airway function and ultimately airway obstruction throughout...

Trial Type

Observational

Sponsorship

National Institute of Allergy and Infectious Diseases (NIAID)

Clinicaltrials.gov

Longitudinal Observational Study of Severe Asthma

Background: - Asthma is a lung condition that causes difficulty breathing and decreased lung function. Some people with asthma have more severe disease symptoms. They may be less responsive to standard...

Trial Type

Observational

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

TGF-(Beta) and Susceptibility to RSV

Background: - Human respiratory syncytial virus (RSV) is a virus that causes respiratory tract infections, and is frequently responsible for hospital visits in infants and children. It can also trigger severe...

Trial Type

Observational

Sponsorship

National Institute of Environmental Health Sciences (NIEHS)

Clinicaltrials.gov

A Study to Assess the Efficacy and Safety of Multiple Dose Levels of...

This study will assess the efficacy and safety of multiple dose levels of AZD7594 administered once daily (QD) by inhalation in a 12-week treatment period on asthma subjects. The activity will be assessed by...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

Parexel

Clinicaltrials.gov

Pilot of Lifestyle and Asthma Intervention

This is to pilot test a weight loss intervention in obese patients with poorly controlled asthma. Obesity is a risk factor for the development of asthma (approximately 250,000 cases per year of asthma in the...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

University of Arizona

Clinicaltrials.gov

Assessment of the Safety and Efficacy of Dupilumab in Children With...

Primary Objective: To evaluate the long-term safety and tolerability of dupilumab in pediatric patients with asthma who participated in a previous dupilumab asthma clinical study. Secondary Objectives: - To...

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

Regeneron Pharmaceuticals

Clinicaltrials.gov

Adapting and Expanding the Asthma-Educator App

This project seeks to test and refine an adapted/expanded version of a previously created ASTHMAXcel app.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Montefiore Medical Center

Clinicaltrials.gov

Kids 2 Be & Breathe: A Study on the Use of Yoga and Mindfulness in...

This proposed pilot study will examine the tolerability, feasibility, acceptability, and preliminary effects of a gentle yoga intervention "Kids 2 Be & Breathe" (K2B2; a manualized 30 minute gentle yoga and...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Virginia Commonwealth University

Clinicaltrials.gov

The Dallas Asthma Brain and Cognition (ABC) Study

Asthma is a chronic inflammatory airway disease that leads to episodic symptom exacerbations, which exerts a substantial burden on quality of life and can influence other health domains if not adequately...

Trial Type

Observational

Sponsorship

Southern Methodist University

Clinicaltrials.gov

Incentives for Adherence in Adolescent Asthma

Financial incentives have been suggested as a possible means for increasing adherence to asthma medications. This study will evaluate an incentive strategy (daily small reward for adherence) in maintaining...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

University of Colorado, Denver

Clinicaltrials.gov

Aligning With Schools To Help Manage Asthma (Project ASTHMA)

Project ASTHMA is a school-based health center intervention program that institutes guideline-based chronic asthma care and provides supervised administration with daily preventive asthma medications to...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

State University of New York at Buffalo

Clinicaltrials.gov

Reslizumab in the Treatment of Eosinophilic Granulomatosis With...

Reslizumab is a type of medicine called a monoclonal antibody that is made in the research clinic; it works by blocking a specific protein in the body called interleukin-5. The study medicine, reslizumab, is...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

Teva Pharmaceuticals USA

Clinicaltrials.gov

Association of Transcutaneous Pulse CO-oximetry With Inflammatory...

This is a pilot cross-sectional study of measured transcutaneous CO-oximetry in children with inflammatory and non-inflammatory conditions.

Trial Type

Observational

Sponsorship

Boston Children’s Hospital

Clinicaltrials.gov

Registry for Asthma Characterization and Recruitment 2

There is a need for people to take part in research studies to learn more about diseases and how to treat them. The Registry for Asthma Characterization and Recruitment 2 (RACR2) will create a database of...

Trial Type

Observational [Patient Registry]

Sponsorship

Inner-City Asthma Consortium

Clinicaltrials.gov

The Effects of NOx and Conjugated Linoleic Acid on Asthmatics

This study will examine the hypothesis that in obese asthmatics; treatment with NOx + CLA is well tolerated, safe and will increase eNO while reducing airway oxidative stress. Allied with this, the...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

Gladwin, Mark, MD

Clinicaltrials.gov

Characterization of Adult Subjects for Asthmatic Research Studies

This study is designed to characterize subjects in terms of the nature and severity of their asthma and in terms of conditions that may alter the clinical expression of asthma. Some features will be obtained...

Trial Type

Observational

Sponsorship

University of California, San Francisco

Clinicaltrials.gov

Vaginal Microbiome Exposure and Immune Responses in C-section Infants

The purpose of this research study is to assess at how differences in the microbiome (naturally occurring bacteria) of a baby may protect, or put a baby at risk, for allergic problems. The microbiome refers to...

Trial Type

Interventional

Trial Phase

Early Phase 1

Sponsorship

Immune Tolerance Network (ITN)

Clinicaltrials.gov

Peer-Administered Asthma Self-Management Intervention in Urban Middle...

Health disparities in pediatric asthma persist, with Latino children demonstrating increased asthma morbidity. Middle school children with asthma have greater morbidity than children from any other age group...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

University of Puerto Rico

Clinicaltrials.gov

Continuation of TRAVERSE- LTS12551 Evaluating Dupilumab Safety in...

Primary Objective: To describe the long-term safety of dupilumab in treatment of patients with moderate to severe asthma who completed the previous asthma clinical trial (TRAVERSE-LTS12551).

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

Regeneron Pharmaceuticals

Clinicaltrials.gov

Trial of Tauroursodeoxycholic Acid (TUDCA) in Asthma

Asthma is a chronic lung disease that affects millions of people worldwide, including both children and adults. The cause of asthma is not known, but asthma is strongly associated with inflammation of the...

Trial Type

Interventional

Trial Phase

Phase 1

Sponsorship

University of Vermont

Clinicaltrials.gov

Inpatient Clinical Trial of NAC

The purpose of this study is to determine the beneficial effect of n-acetylcysteine (NAC), an inhaled medication that breaks down mucus, on lung function. NAC is a medication approved by the US Food and Drug...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

National Institutes of Health (NIH)

Clinicaltrials.gov

Clinical Endpoint Bioequivalence Study of Fluticasone Propionate &...

A Randomized, Parallel-Group, Placebo-Controlled, Clinical Endpoint Bioequivalence Study of Generic Fluticasone Propionate 100 μg and Salmeterol Xinafoate 50 μg Inhalation Powder Compared with Advair Diskus®...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

West-Ward Pharmaceutical

Clinicaltrials.gov

Peak Expiratory Flow Rate for Emergency Department Management of...

Patients presenting to the emergency department with acute asthma exacerbation will be assigned to peak-expiratory flow rate (PEFR) guided management and non-PEFR guided management.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Hennepin Healthcare Research Institute.

Clinicaltrials.gov

Ginger's Therapeutic Potential in Asthma

This is a randomized, double blind, placebo controlled study to study whether there are potential benefits of consuming ginger by individuals with asthma.

Trial Type

Interventional

Trial Phase

Early Phase 1

Sponsorship

National Center for Complementary and Integrative Health (NCCIH)

Clinicaltrials.gov

Benralizumab in the Treatment of Eosinophilic Granulomatosis With...

Benralizumab is a type of medicine called a monoclonal antibody that is made in the research clinic; it works by blocking a specific protein in the body called interleukin-5. The study medicine, benralizumab,...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

AstraZeneca

Clinicaltrials.gov

Electronic Monitoring of Medication Adherence in Moderate to Severe...

This study will evaluate the role of using electronic sensors for asthma inhaler devices in monitoring medication adherence and asthma control

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Stony Wold-Herbert Fund, Inc.

Clinicaltrials.gov

AIRWEIGHS: Investigating Obesity as a Susceptibility Factor for Air...

Background: Asthma and obesity are public health crises that have concurrently risen over the past decades, affecting millions of children in the United States and disproportionately affecting low-income...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Johns Hopkins University

Clinicaltrials.gov

Preventing Asthma in High Risk Kids

This trial is a randomized, double-blind, placebo controlled trial designed to test whether two years treatment of preschool children aged 2-3 years of age at high risk for asthma with omalizumab (anti-IgE)...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

National Institute of Allergy and Infectious Diseases (NIAID)

Clinicaltrials.gov

Immune Interactions in Severe Asthma

This research study is being done to learn more about severe asthma by comparing people with severe asthma to those with milder forms of asthma and people without asthma, at baseline and over time. Individuals...

Trial Type

Observational

Sponsorship

University of Pittsburgh

Clinicaltrials.gov

Randomized, Placebo-controlled, Multi-dose, Study Comparing...

A randomized multiple-dose, placebo-controlled, parallel group design consisting of a 2-week run-in period followed by a 6-week treatment period of the placebo, Test product (Budesonide 80 mcg / Formoterol...

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

Actavis Inc.

Clinicaltrials.gov

Mechanism(s) of Airflow Limitation During Exacerbation of Asthma

The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Gelb, Arthur F., M.D.

Clinicaltrials.gov

The Genetics of Severe Asthma in Children

Near fatal asthma exacerbations are one of the most common causes of critical illness in children, accounting for approximately ten thousand intensive care unit (ICU) admissions per year in the United States....

Trial Type

Observational

Sponsorship

UConn Health

Clinicaltrials.gov

Inflammatory Mediators and microRNA Analysis in Premenstrual Asthma

A small number of women with asthma have an increase in asthma symptoms during the premenstrual or menstrual period. This study is being done to investigate the possible causes of this premenstrual increase in...

Trial Type

Observational

Sponsorship

Ohio State University

Clinicaltrials.gov

Feasibility and Acceptability of the Hailie Monitoring System in...

The main hypothesis of this study is to see if children and adolescents with poorly controlled asthma will find the Hailie Smart Inhaler electronic monitoring device is feasible and acceptable, and will result...

Trial Type

Observational

Sponsorship

Connecticut Children's Medical Center

Clinicaltrials.gov

Study to Evaluate Efficacy and Safety of Benralizumab in Reducing...

This is a study designed to evaluate efficacy and safety of Benralizumab in reducing the Oral Corticosteroid (OCS) use in adult patients with severe asthma who are receiving OCS with or without additional...

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

AstraZeneca

Clinicaltrials.gov

Study to Evaluate Tezepelumab in Adults & Adolescents With Severe...

A Multicentre, Randomized, Double-Blind, Placebo Controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Tezepelumab in Adults and Adolescents with Severe Uncontrolled Asthma

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

Amgen

Clinicaltrials.gov

RVA Breathes: A Richmond City Collaboration to Reduce Pediatric...

The goal of this study is to evaluate a sustainable, community-engaged program to reduce asthma disparities among 5 to 11-year-old children in Richmond, Virginia. Richmond, an urban center, has been named the...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

Detroit Young Adult Asthma Project

The purpose of the Detroit Young Adult Asthma Project is to test a technology based program to help African American young adults learn to better manage their asthma. Participants will be randomized to a...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

Cysteamine for Asthma

The purpose of this study is to see if a medicine called Cysteamine, given along with standard asthma care, will improve asthma symptoms and lung function.

Trial Type

Interventional

Trial Phase

Phase 1

Sponsorship

Children's Hospital Medical Center, Cincinnati

Clinicaltrials.gov

The Study is Enrolling Kids From 7 to 16 Years Old. The BreathSmart...

Non-adherence to controller medication is a common problem in children with Asthma, resulting in overuse of reliever medication, increased asthma symptoms, more frequent Asthma attacks, and increased emergency...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Connecticut Children's Medical Center

Clinicaltrials.gov

Trial of Roflumilast in Asthma Management (TRIM)

There are currently no treatments to specifically target asthma in obese adults. This pilot study is being conducted to investigate how effective roflumilast is in treating asthma in participants that have a...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

A Study of Gamma Tocopherol-enriched Supplement on Lower Airway...

Purpose: To determine the efficacy of 1400 mg gamma tocopherol-enriched supplement for mitigating inhaled wood smoke particle-induced airway inflammation in healthy adults with no more than mild asthma.

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

National Institute of Environmental Health Sciences (NIEHS)

From the latest relevant research and Asthma expert interviews to personal stories and advice on managing your symptoms, here’s everything about Asthma that’s making headlines.

MPR

Switching and Combining Biologics for the Treatment of Severe Asthma

Without any head-to-head data or algorithms on the optimum method of choosing between the newly introduced biologics for the treatment of severe asthma, clinicians must observe patient clinical response after adequate trial periods, and then make changes as necessary, according to research presented at the American Thoracic Society’s International Conference, held May 17 to 22, in Dallas, Texas.

Learn More

Medscape

European Commission OKs Dupilumab (Dupixent) for Severe Asthma

The European Commission (EC) has approved dupilumab (Dupixent, Sanofi/Regeneron) as add-on maintenance therapy for patients aged 12 years or older with severe asthma with type 2 inflammation characterized by increased blood eosinophil levels and/or increased fractional exhaled nitric oxide, whose condition is poorly controlled with high-dose inhaled corticosteroid plus another medicine.

Learn More

EurekaAlert

Long-term use of benralizumab appears safe, effective for severe asthma

Patients with severe eosinophilic asthma, who participated in three different Phase 3 trials of benralizumab (brand name Fasenra) and then enrolled in a long-term trial of the drug's efficacy and safety, continued to experience fewer exacerbations and improved pulmonary function and quality of life, according to research presented at ATS 2019.

Learn More

Pulmonology Advisor

Severe Asthma: Harnessing Biomarkers to Power Treatment Effectiveness

Dr Nicola Davies explores how phenotypes, endotypes, and biomarkers can be used to predict and assess treatment effectiveness for severe asthma.

Learn More

PRWeb

New Study Sheds Light on the Challenges and Barriers of Severe Asthma Management

Though the majority of asthmatic patients experience mild to moderate symptoms, those with severe asthma face increased challenges when it comes to asthma management. A new but small study from The Journal of Allergy and Clinical Immunology: In Practice (JACI: In Practice) highlights the support gaps that still need to be filled for patients living with severe asthma.

Learn More

FiercePharma

AstraZeneca's Fasenra offers severe asthma patients 2 years of benefits: analysis

AstraZeneca’s Fasenra has been stealing share from GlaxoSmithKline’s Nucala in severe asthma, and competition is even fiercer with Sanofi’s Dupixent approval. Now, AZ has released an analysis of several trials showing Fasenra's positive effects for patients last up to two years.

Learn More

Whether you’re considering participating in a clinical trial or just looking for more information about Asthma, we want you to keep you informed about living with Asthma, your treatment options, and the clinical trial process.