Asthma?

New study treatments that may put you back in control.

The respiratory condition that can make breathing difficult has several options on the market. But for those who still struggle with attacks, we’re working on giving you new options. Learn about the cutting-edge study treatments being investigated near you.

of Americans
have been diagnosed with severe Asthma. ¹

1.5

million people
use an inhaler everyday

100s

of treatments on the market
None of them a pill that stop attacks

I wish there was something else like a pill that you take once a week or per month to help with airwaves and breathing so I didn’t have to take the inhaler everywhere. That would be nice.

Patient

7 years with Asthma

I take my inhaler with me everywhere, I’m a control freak. My backpack always has water, cliff bar, allergy meds, and of course my inhaler is always in there too.

Patient

21 years with Asthma

Asthma Clinical Trials

Learn about the newest Asthma study treatments now being investigated, including cutting-edge options available to clinical trial participants.

TrialSpark is now recruiting for a trial that tests the effectiveness of a study drug for Asthma symptoms.

Learn more

A new asthma drug candidate called fevipiprant

The overall purpose of this study is to determine the efficacy of fevipiprant (dose 1 and dose 2 once daily), compared with placebo, as add-on to standard-of-care asthma therapy, in terms of avoidance of...

Compensation

N/A

Trial Type

Interventional

Sponsorship

Novartis

Clinicaltrials.gov

Evaluating Efficacy of Smart Device in Assisting With Inhaler...

Asthma affects over 10 million children in the U.S., and poses a significant health and cost burden. Metered dose inhaler (MDI) is the most common method of treatment. Studies show that up to 80% of patients...

Trial Type

Interventional

Trial Phase

Early Phase 1

Sponsorship

Cognita Labs LLC

Clinicaltrials.gov

The Dallas Asthma Brain and Cognition (ABC) Study

Asthma is a chronic inflammatory airway disease that leads to episodic symptom exacerbations, which exerts a substantial burden on quality of life and can influence other health domains if not adequately...

Trial Type

Observational

Sponsorship

Southern Methodist University

Clinicaltrials.gov

New Approaches for Empowering Studies of Asthma in Populations of...

Background: Some groups of people have a high prevalence of asthma and allergic disease. Also, asthma and allergic disease are often found in several members of the same family. Researchers want to learn more...

Trial Type

Observational

Sponsorship

National Human Genome Research Institute (NHGRI)

Clinicaltrials.gov

Adapting and Expanding the Asthma-Educator App

This project seeks to test and refine an adapted/expanded version of a previously created ASTHMAXcel app.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Montefiore Medical Center

Clinicaltrials.gov

AdheRence to Inhaled Corticosteroids in Asthma

It is widely recognized that asthma in adult African American patients is a significant health problem, which is partly affected by relatively low inhaled corticosteroid (ICS) adherence rates. The goal of this...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Duke University

Clinicaltrials.gov

Continuation of TRAVERSE- LTS12551 Evaluating Dupilumab Safety in...

Primary Objective: To describe the long-term safety of dupilumab in treatment of patients with moderate to severe asthma who completed the previous asthma clinical trial (TRAVERSE-LTS12551).

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

Regeneron Pharmaceuticals

Clinicaltrials.gov

Vaginal Microbiome Exposure and Immune Responses in C-section Infants

The purpose of this research study is to assess at how differences in the microbiome (naturally occurring bacteria) of a baby may protect, or put a baby at risk, for allergic problems. The microbiome refers to...

Trial Type

Interventional

Trial Phase

Early Phase 1

Sponsorship

Immune Tolerance Network (ITN)

Clinicaltrials.gov

Peer-Administered Asthma Self-Management Intervention in Urban Middle...

Health disparities in pediatric asthma persist, with Latino children demonstrating increased asthma morbidity. Middle school children with asthma have greater morbidity than children from any other age group...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

University of Puerto Rico

Clinicaltrials.gov

Aligning With Schools To Help Manage Asthma (Project ASTHMA)

Project ASTHMA is a school-based health center intervention program that institutes guideline-based chronic asthma care and provides supervised administration with daily preventive asthma medications to...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

State University of New York at Buffalo

Clinicaltrials.gov

Registry for Asthma Characterization and Recruitment 2

There is a need for people to take part in research studies to learn more about diseases and how to treat them. The Registry for Asthma Characterization and Recruitment 2 (RACR2) will create a database of...

Trial Type

Observational [Patient Registry]

Sponsorship

Inner-City Asthma Consortium

Clinicaltrials.gov

Characterization of Adult Subjects for Asthmatic Research Studies

This study is designed to characterize subjects in terms of the nature and severity of their asthma and in terms of conditions that may alter the clinical expression of asthma. Some features will be obtained...

Trial Type

Observational

Sponsorship

University of California, San Francisco

Clinicaltrials.gov

Dexpramipexole Dose-Ranging Biomarker Study in Subjects With...

This is a randomized, double-blind, placebo-controlled, parallel-group, dose-ranging, multi-center study to evaluate the clinical effects of oral administration of dexpramipexole for 12 weeks on peripheral...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

Knopp Biosciences

Clinicaltrials.gov

The Tailored Adherence Incentives for Childhood Asthma Medications...

Improving adherence to inhaled corticosteroids (ICS) medication in urban minority pediatric populations is a clinical and population health priority. Financial incentives have been shown as a compelling method...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

Clinic Navigation and Home Visits to Improve Guideline-based Care and...

Asthma-related deaths are more numerous among low-income minority patients and older adults with chronic diseases. Guidelines for asthma management have not addressed the needs of these groups. The...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

Technology-Assisted Stepped Care Study

The overall goal of this project is to demonstrate the feasibility, implementation, and preliminary efficacy of a technology-assisted stepped care (TASC) adherence-promotion intervention in adolescents with...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Children's Hospital Medical Center, Cincinnati

Clinicaltrials.gov

Technology- Assisted Stepped Care Intervention Study

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Children's Hospital Medical Center, Cincinnati

Clinicaltrials.gov

Safety of LAIV4 in Children With Asthma

This is a prospective randomized, open label clinical trial in approximately 300 children aged 5-11 years with a physician diagnosis of persistent asthma. Participants will be randomized 1:1 to receive either...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

Children's Hospital Medical Center, Cincinnati

Clinicaltrials.gov

Translating an Efficacious Illness Management Intervention for Youth...

The propose of the study is to test the effectiveness of Reach for Control (RFC) as compared to Michigan MATCH to improve asthma symptoms, asthma management and lung functioning and to decrease ED visits and...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

A Trial of Mepolizumab Adjunctive Therapy for the Prevention of...

The purpose of this study is to see if treatment with a medication called Nucala® (mepolizumab), given along with standard asthma care, makes children less likely to have asthma attacks.

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

GlaxoSmithKline

Clinicaltrials.gov

Screening Inhaled Allergen Challenge for Dermatophagoides Farinae

This study is designed to identify Dermatophagoides farinae, or Der f, sensitive asthmatics who demonstrate a late phase asthmatic response after Der f inhalation. These subjects may be invited to participate...

Trial Type

Interventional

Trial Phase

Early Phase 1

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

Patient Empowered Strategy to Reduce Asthma Morbidity in Highly...

Asthma imposes a significant burden in the US in terms of morbidity, costs to society, individual suffering, loss of productivity and mortality. African Americans (AA) and Hispanic/Latinos (H/L) bear a...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

American Academy of Family Physicians

Clinicaltrials.gov

Increased Lung Volume as Controller Therapy for Asthma

This is an early phase clinical trial to test the efficacy of elevating lung volume with positive expiratory pressure (CPAP) as a controller therapy for asthma in patients with a BMI ≥ 30 kg/m2. There will be...

Trial Type

Interventional

Trial Phase

Phase 1/Phase 2

Sponsorship

Icahn School of Medicine Mount Sinai, NY

Clinicaltrials.gov

Sorting and Expression Profiling of Airway Cells From Humans (The...

This will be a single site, mechanistic study of asthmatic subjects and healthy, non-asthmatic controls involving a baseline characterization visit and a research bronchoscopy visit. We will identify...

Trial Type

Observational

Sponsorship

National Institute of Allergy and Infectious Diseases (NIAID)

Clinicaltrials.gov

Trial of AccuPAP Device Versus Standard Nebulizer Therapy in Acute...

The objective of this randomized control trial is to investigate the efficacy of an adjunct positive airway pressure (PAP) nebulizer device known as "AccuPAP" in the treatment of moderate-severity acute asthma...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Vanderbilt University Medical Center

Clinicaltrials.gov

Mechanisms of Exacerbation of Asthma

The purpose of this study is to identify the causes of asthma that were not previously suspected, to better understand the effects of inhaled steroids on asthma and to identify new way to treat asthma.

Trial Type

Observational

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

Environmental Polymorphisms Registry

This study conducted by the NIEHS and the University of North Carolina Medical Center will create and maintain a biorespository containing the genetic material (DNA) from up to 20,000 individuals recruited...

Trial Type

Observational

Sponsorship

National Institute of Environmental Health Sciences (NIEHS)

Clinicaltrials.gov

Genotype-tailored Treatment of Symptomatic Acid-Reflux in Children...

This study will evaluate the effect of CYP2C19 and ABCB1 genes on pharmacokinetics of lansoprazole in children with mild gastroesophageal reflux (GER) and uncontrolled asthma. It will determine if...

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

Nemours Children's Clinic

Clinicaltrials.gov

Asthma and Obesity: Pilot Study

Develop and pilot test four theory-based educational modules that integrate counseling for asthma and obesity to promote greater physical activity among people with asthma.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

An Asthma Mobile Intervention to Promote Patient-Reported Outcomes in...

Through this study, the investigators will adapt the ASTHMAXcel mobile app and evaluate the adapted intervention through a randomized controlled trial.

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

Montefiore Medical Center

Clinicaltrials.gov

Technology Enabled Asthma Management System (TEAMS) Pilot Study

To evaluate feasibility, acceptability, safety, and preliminary efficacy of a novel patient-centered, technology-based intervention to improve asthma care in younger adult smartphone users. The program, called...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

University of Rhode Island

Clinicaltrials.gov

The Effect of Cetirizine on Bronchoconstriction

The purpose of this study is to determine the effect of cetirizine, an oral antihistamine, on wheezing in patients with allergic rhinitis. Patients presenting to the pediatric emergency department who have a...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

New York City Health and Hospitals Corporation

Clinicaltrials.gov

Pneumococcal Vaccines in Patients With Asthma

Investigators are assessing if patients with asthma respond better to the Pneumovax vaccine if they are given Prevnar initially.

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

Mayo Clinic

Clinicaltrials.gov

Treating Caregiver Depression to Improve Childhood Asthma: Impact and...

The investigators propose a one-year, repeated measures, within-subject design to examine the impact of improved caregiver depression on child asthma outcomes. A cross-lagged panel modeling (CLPM) for...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

University at Buffalo

Clinicaltrials.gov

Biomarkers of Irritant-Induced and Allergic Asthma

Asthma is a heterogeneous disease, and although much is understood about mechanisms of inflammation in allergic asthma, less is known about mechanisms of irritant-induced asthma (IA). Understanding the...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

NYU Langone Health

Clinicaltrials.gov

Upper Airway Microbial Development During the First Year of Life

This study tests the hypothesis that an increase in pathogenic bacteria within the infant airway leads to increased airway inflammation, decreased airway function and ultimately airway obstruction throughout...

Trial Type

Observational

Sponsorship

National Institute of Allergy and Infectious Diseases (NIAID)

Clinicaltrials.gov

Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma

The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory...

Trial Type

Observational

Sponsorship

Gelb, Arthur F., M.D.

Clinicaltrials.gov

Assessment of the Safety and Efficacy of Dupilumab in Children With...

Primary Objective: To evaluate the long-term safety and tolerability of dupilumab in pediatric patients with asthma who participated in a previous dupilumab asthma clinical study. Secondary Objectives: - To...

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

Regeneron Pharmaceuticals

Clinicaltrials.gov

TGF-(Beta) and Susceptibility to RSV

Background: - Human respiratory syncytial virus (RSV) is a virus that causes respiratory tract infections, and is frequently responsible for hospital visits in infants and children. It can also trigger severe...

Trial Type

Observational

Sponsorship

National Institute of Environmental Health Sciences (NIEHS)

Clinicaltrials.gov

Longitudinal Observational Study of Severe Asthma

Background: - Asthma is a lung condition that causes difficulty breathing and decreased lung function. Some people with asthma have more severe disease symptoms. They may be less responsive to standard...

Trial Type

Observational

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

Pilot of Lifestyle and Asthma Intervention

This is to pilot test a weight loss intervention in obese patients with poorly controlled asthma. Obesity is a risk factor for the development of asthma (approximately 250,000 cases per year of asthma in the...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

University of Arizona

Clinicaltrials.gov

Observational Study of Characteristics, Treatment and Outcomes With...

The CHRONICLE Study is a multi-center, non-interventional, prospective cohort study of adults with severe asthma who do not achieve control with high-dose inhaled corticosteroid (ICS) therapy with additional...

Trial Type

Observational [Patient Registry]

Sponsorship

MedImmune LLC

Clinicaltrials.gov

Airway Temperature

Airway irritation, cough and bronchial spasm are common symptoms in patients with airway inflammatory diseases such as asthma. The primary focus of this exploratory study is to determine if there is an...

Trial Type

Interventional

Trial Phase

Phase 1

Sponsorship

National Institute of Allergy and Infectious Diseases (NIAID)

Clinicaltrials.gov

Phosphodiesterase 4 Inhibitor, Roflumilast, and the Effects of...

This study evaluates the effects of roflumilast on restoring response β2 adrenoreceptor agonists in low T2, obese asthmatics. One group of participants will receive roflumilast for 3 months, while the other...

Trial Type

Interventional

Trial Phase

Phase 1

Sponsorship

University of California, Davis

Clinicaltrials.gov

Remote Physician Care for Home Hospital Patients

This study examines the implications of providing remote physician care to home hospitalized patients compared to usual home hospital care with in-person/in-home physician visits.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Brigham and Women's Hospital

Clinicaltrials.gov

Symptom Clusters in Children With Exacerbation-prone Asthma

Pediatric participants with exacerbation-prone asthma will receive an intramuscular injection of triamcinolone acetonide and will be followed for 48 weeks. The study visit 2 weeks after the injection will...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

National Institute of Nursing Research (NINR)

Clinicaltrials.gov

Study in Adult Asthmatic Patients With Allergic Bronchopulmonary...

A Randomized, Double-Blind, Multicenter, Placebo-Controlled, Phase 2 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Itraconazole Administered as a Dry Powder for Inhalation (PUR1900) in...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

Pulmatrix Inc.

Clinicaltrials.gov

The Effect of NAC on Lung Function and CT Mucus Score

This study evaluates 20% n-acetylcysteine (NAC) in the treatment of moderate-to-severe asthma that is complicated by mucus in the airway, as determined by CT imaging. The study is a crossover design, which...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

University of California, San Francisco

Clinicaltrials.gov

Ginger's Therapeutic Potential in Asthma

This is a randomized, double blind, placebo controlled study to study whether there are potential benefits of consuming ginger by individuals with asthma.

Trial Type

Interventional

Trial Phase

Early Phase 1

Sponsorship

National Center for Complementary and Integrative Health (NCCIH)

Clinicaltrials.gov

PCORI Integrated Care (IC) Models for Patient-Centered Outcomes

Multiple chronic conditions (MCC) are widely recognized as the U.S. public health challenge of the 21st century. These physical and behavioral health conditions take a large toll on those suffering from the...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Patient-Centered Outcomes Research Institute

Clinicaltrials.gov

Peak Expiratory Flow Rate for Emergency Department Management of...

Patients presenting to the emergency department with acute asthma exacerbation will be assigned to peak-expiratory flow rate (PEFR) guided management and non-PEFR guided management.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Hennepin Healthcare Research Institute.

From the latest relevant research and Asthma expert interviews to personal stories and advice on managing your symptoms, here’s everything about Asthma that’s making headlines.

MPR

Switching and Combining Biologics for the Treatment of Severe Asthma

Without any head-to-head data or algorithms on the optimum method of choosing between the newly introduced biologics for the treatment of severe asthma, clinicians must observe patient clinical response after adequate trial periods, and then make changes as necessary, according to research presented at the American Thoracic Society’s International Conference, held May 17 to 22, in Dallas, Texas.

Learn More

Medscape

European Commission OKs Dupilumab (Dupixent) for Severe Asthma

The European Commission (EC) has approved dupilumab (Dupixent, Sanofi/Regeneron) as add-on maintenance therapy for patients aged 12 years or older with severe asthma with type 2 inflammation characterized by increased blood eosinophil levels and/or increased fractional exhaled nitric oxide, whose condition is poorly controlled with high-dose inhaled corticosteroid plus another medicine.

Learn More

EurekaAlert

Long-term use of benralizumab appears safe, effective for severe asthma

Patients with severe eosinophilic asthma, who participated in three different Phase 3 trials of benralizumab (brand name Fasenra) and then enrolled in a long-term trial of the drug's efficacy and safety, continued to experience fewer exacerbations and improved pulmonary function and quality of life, according to research presented at ATS 2019.

Learn More

Pulmonology Advisor

Severe Asthma: Harnessing Biomarkers to Power Treatment Effectiveness

Dr Nicola Davies explores how phenotypes, endotypes, and biomarkers can be used to predict and assess treatment effectiveness for severe asthma.

Learn More

PRWeb

New Study Sheds Light on the Challenges and Barriers of Severe Asthma Management

Though the majority of asthmatic patients experience mild to moderate symptoms, those with severe asthma face increased challenges when it comes to asthma management. A new but small study from The Journal of Allergy and Clinical Immunology: In Practice (JACI: In Practice) highlights the support gaps that still need to be filled for patients living with severe asthma.

Learn More

FiercePharma

AstraZeneca's Fasenra offers severe asthma patients 2 years of benefits: analysis

AstraZeneca’s Fasenra has been stealing share from GlaxoSmithKline’s Nucala in severe asthma, and competition is even fiercer with Sanofi’s Dupixent approval. Now, AZ has released an analysis of several trials showing Fasenra's positive effects for patients last up to two years.

Learn More

Whether you’re considering participating in a clinical trial or just looking for more information about Asthma, we want you to keep you informed about living with Asthma, your treatment options, and the clinical trial process.