COPD?

Rethink your treatment options.

Chronic obstructive pulmonary disease (COPD) is a chronic disease usually caused by exposure to noxious particles or gases like cigarette smoke. Symptoms like coughing, shortness of breath, and wheezing make it difficult to keep up with normal activities, but we’re working on new options. Learn about the cutting-edge study treatments being investigated near you.

1/5

Americans age 45 years and older has COPD. ¹

37%

Women are 37% more likely to have COPD than men. ²

70%

of people with COPD say it limits physical activity. ³

COPD Clinical Trials

Learn about the newest COPD study treatments now being investigated, including cutting-edge study options available to clinical trial participants.

TrialSpark is now recruiting for a trial that tests the effectiveness of a cystic fibrosis drug on COPD symptoms.

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Clinicaltrials.gov

Peak Inspiratory Flow Rates in Patients With COPD

Recent studies have reported that some COPD patients may have a suboptimal ability to generate a sufficient inspiratory effort to achieve adequate lung delivery of inhaled medications through dry powder...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Boehringer Ingelheim

Clinicaltrials.gov

Active for Life: Chronic Obstructive Pulmonary Disease

This study examines the effects of an exercise and behavioral program, called Active-Life, to promote physical activity in people with chronic obstructive pulmonary disease. A sedentary lifestyle is very...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

University of Michigan

Clinicaltrials.gov

Imaging of Apoptosis in Chronic Obstructive Pulmonary Disease (COPD)

This will be a prospective study examining the use of 99mTc-Annexin V-128 (AxV-128/Tc) single-photon emission computed tomography (SPECT)/computerized tomography (CT) technology in the imaging and functional...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

HFNC Effect on BCSS in Patients With COPD

The primary objective of this study is to look for a correlation between the use of HFNC in the outpatient setting in patients with previous COPD exacerbation and the change in their BCSS score. The hypothesis...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Fisher and Paykel Healthcare

Clinicaltrials.gov

Integrative-omics of the Disordered COPD Small Airway Epithelium

We aim to use an integrated network systems approach to analyze certain existing small airway epithelium (SAE) omic data sets at the genetic, epigenetic (methylation), gene expression, microRNA and metabolomic...

Trial Type

Observational

Sponsorship

Weill Medical College of Cornell University

Clinicaltrials.gov

Fish Oil and HMB Supplementation in COPD

In the present study, the role of chronic (10 weeks) intake of low dose (2g/day) of EPA+DHA in whole body protein metabolism, and functional performance and systemic inflammation will be examined, and whether...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Texas A&M University

Clinicaltrials.gov

Nebulizer Versus Dry Powdered Inhalers for COPD

This will be a non-blinded feasibility (pilot) study comparing triple therapy nebulizer vs dry powdered inhalers (DPI) for care transitions in COPD exacerbation patients. We hypothesize that patients treated...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

Wake Forest University Health Sciences

Clinicaltrials.gov

The Topic Trial - Study to Determine the Safety and Efficacy of...

The study is a Phase 2 Study to establish the safety and efficacy of a drug called Ivacaftor (VX-770) in patients with chronic obstructive pulmonary disease (COPD), chronic bronchitis, and acquired CFTR...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

Vertex Pharmaceuticals Incorporated

Clinicaltrials.gov

Randomized Evaluation of Default Access to Palliative Services

This is a large pragmatic, randomized controlled trial to test the real-world effectiveness of inpatient palliative care consultative services in improving a number of patient- and family-centered processes...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Institute on Aging (NIA)

Clinicaltrials.gov

COPD Metabolome, Smoking Oxidants and Aberrant Ciliated Cell Function

Cigarette smoking is the major cause of chronic obstructive pulmonary disease (COPD), the 4th cause of mortality in the US. Central to COPD pathogenesis is "ciliopathy", dysfunction of the airway ciliated...

Trial Type

Observational

Sponsorship

Weill Medical College of Cornell University

Clinicaltrials.gov

Improving Cardiovascular Health in Patients With Chronic Obstructive...

Researchers have found a link between chronic obstructive pulmonary disease (COPD) and heart disease; however, a link is all they have found. Cardiovascular health in COPD is controlled by different mechanisms...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Virginia Commonwealth University

Clinicaltrials.gov

Increasing Adherence to Pulmonary Rehabilitation After COPD Related...

This study will look at the effectiveness of a home-based Pulmonary Rehabilitation Program in patients who have recently been hospitalized for a COPD related cause.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

Evaluation of the Safety and Efficacy of TLD in Patients With COPD

The purpose of this study is to confirm the safety and efficacy of the Nuvaira Lung Denervation System (Nuvaira System) in the treatment of COPD.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Nuvaira, Inc.

Clinicaltrials.gov

Static Lung Hyperinflation and Sympathetic Nerve Activity-Associated...

The goal of this study is to evaluate the acute effects of a long-acting bronchodilator on pulmonary function, vascular function and muscle sympathetic nerve activity in individuals with COPD. Individuals will...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

Gary L. Pierce

Clinicaltrials.gov

The CAPTURE Study: Validating a Unique COPD Case Finding Tool in...

A prospective, multicenter study including a cross-section validation to define sensitivity and specificity of CAPTURE to identify previously undiagnosed patients with clinically significant Chronic...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

COPD Foundation

Clinicaltrials.gov

Rehabilitation in Safety-net Settings for Patients With COPD

This study will examine COPD Wellness, a 10-week low-intensity pulmonary rehabilitation program consisting of group and home exercise, education, and social support can improve symptoms and increase physical...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Nina Ireland Program in Lung Health

Clinicaltrials.gov

Pulmonary Rehab in COPD: Response to Tyvaso

The investigators' hypothesis is that pretreating patients with COPD with inhaled treprostinil prior to pulmonary rehabilitation sessions will result in improved exercise tolerance during sessions. This in...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

Inova Health Care Services

Clinicaltrials.gov

Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study

Chronic obstructive pulmonary disease (COPD) is often caused by cigarette smoking, but genetic predisposition also influences COPD susceptibility. The purpose of this study is to identify genetic factors that...

Trial Type

Observational

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

A Clinical Study to Investigate if a Single Dose of an Approved Drug...

A clinical study to investigate if a single dose of an approved drug product (glycopyrrolate Inhalation Solution) reduces trapped air in the lungs of participants with chronic obstructive pulmonary disease....

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

Sunovion Respiratory Development Inc.

Clinicaltrials.gov

Implications of Appropriate Use of Inhalers in Chronic Obstructive...

Using various types of inhalers is the treatment cornerstone for COPD patients to control their symptoms. Many inhaler devices require minimum inspiratory effort to activate the device, COPD patients commonly...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

University of Alabama at Birmingham

Clinicaltrials.gov

Biological Effects of Quercetin in COPD

This study determines whether quercetin supplementation reduces the inflammation and oxidative stress markers in patients with chronic obstructive pulmonary disease. It is small study with 8 subjects receive...

Trial Type

Interventional

Trial Phase

Phase 1/Phase 2

Sponsorship

National Center for Complementary and Integrative Health (NCCIH)

Clinicaltrials.gov

Increasing Physical Activity in COPD Through Rhythmically Enhanced...

The VA cares for nearly one million Veterans with COPD at a cost of more than $5.5 billion annually. COPD profoundly impairs quality of life as it limits ability to work, to maintain physical exertion and to...

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

VA Office of Research and Development

Clinicaltrials.gov

The CAPTURE Study: Validating a Unique COPD Case Finding Tool in...

This is a qualitative research exploration engaging clinical staff at all levels from 10 Practice-Based Research Networks (PBRNs) serving US patient populations of differing gender, racial, ethnic, urban/rural...

Trial Type

Observational

Sponsorship

COPD Foundation

Clinicaltrials.gov

The CAPTURE Study: Validating a Unique COPD Case Finding Tool in...

A prospective multi-center study to define the sensitivity and specificity of CAPTURE for identifying previously undiagnosed patients with clinically significant COPD in a broad range of primary care settings.

Trial Type

Observational

Sponsorship

University of Kentucky

Clinicaltrials.gov

High Resolution Micro OCT Imaging

The purpose of this study is to learn about using the imaging to make images of the lungs and nose with the long-term goal of the research leading to potential treatments and new therapies for patients with...

Trial Type

Observational

Sponsorship

Massachusetts General Hospital

Clinicaltrials.gov

Smart Telehealth Exercise Intervention to Reduce COPD Readmissions

This is a prospective randomized controlled study to test the hypothesis that neuromuscular electrical stimulation (NMES) and remote pulmonary rehabilitation at home offered via a smart technology, called...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Institutes of Health (NIH)

Clinicaltrials.gov

Dose of Corticosteroids in COPD

COPD (chronic obstructive pulmonary disease) is a long-lasting lung disease usually caused by long-term smoking. COPD can get worse, making people sick enough to need hospitalization. Corticosteroids are very...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

Rutgers, The State University of New Jersey

Clinicaltrials.gov

A Technology Assisted Care Transition Intervention for Veterans With...

Transition from hospital to home places patients in jeopardy of adverse events and increases their risk for rehospitalization. CHF is the most prevalent chronic condition among U.S. adults and COPD is the...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Northeastern University

Clinicaltrials.gov

Uphill Walking as Exercise for COPD Patients

This study is designed to provide preliminary information regarding how to improve pulmonary rehabilitation for persons with chronic obstructive pulmonary disease (COPD). Pulmonary rehabilitation is an...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

University of Nebraska, Omaha

Clinicaltrials.gov

Study of Humidified Air to Improve Mucociliary Clearance (MCC) in COPD

This purpose of this study is to determine whether nasal delivery of heated and humidified air for a period of 4 hours will improve the clearance of mucus from the lungs of patients with chronic obstructive...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Fisher and Paykel Healthcare

Clinicaltrials.gov

At Home Spirometry and Video Module Education for COPD Patients

The central hypothesis is that patients hospitalized for COPD who subsequently complete the at-home BREATHES Program with V-TTG skill training and SpiroPD adherence support will retain increased medication...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

A Proof-of-mechanism Study of Multiple, Oral Doses of Fevipiprant...

This is an exploratory, randomized, subject- and investigator-blind, placebo-controlled, parallel group, proof-of-mechanism study in approximately 50 COPD patients with eosinophilia.

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

Novartis Pharmaceuticals

Clinicaltrials.gov

Inspiration Point-A Digital Pulmonary Rehabilitation Tool Management...

The purpose of this study is to measure the feasibility of use of a digital pulmonary rehabilitation tool compared with standard care home program pulmonary rehabilitation.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Fusion Health

Clinicaltrials.gov

COPD Access to Pulmonary Rehabilitation Intervention

Persons with COPD have significant functional disability but cannot access rehabilitative treatment at hospital-based conventional pulmonary rehabilitation (PR) programs. This project will determine whether an...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

VA Office of Research and Development

Clinicaltrials.gov

Home Hospital for Suddenly Ill Adults

The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Brigham and Women's Hospital

Clinicaltrials.gov

Long-term Observational Study of the Safety of Roflumilast

This is a retrospective cohort study comparing COPD patients aged 40 years and older with new exposure to roflumilast with up to 5 unexposed (ie, not roflumilast-exposed) COPD controls matched by propensity...

Trial Type

Observational

Sponsorship

AstraZeneca

Clinicaltrials.gov

Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy

Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with...

Trial Type

Interventional

Trial Phase

Phase 1/Phase 2

Sponsorship

University of Virginia

Clinicaltrials.gov

Feasibility of SpiroPD

The investigators' central hypotheses predict that the handheld spirometry device will be feasible for inpatient and at-home use, and is equally efficacious at determining lung function when compared to...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

University of Chicago

Clinicaltrials.gov

Belimumab Treatment of Emphysema Patients With Anti-GRP78...

This is intended to be an initial "proof-of-concept" study to show feasibility, validate assays and approaches, and explore dosing and safety of belimumab in pulmonary emphysema patients who have clinically...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

GlaxoSmithKline

Clinicaltrials.gov

Imaging of Peri-operative (periOP) Lung Injury

The aim of study is to determine if 99mTc Annexin V-128 (AxV- 128/Tc) single photon emission computed tomography (SPECT)-computed tomography (CT) can detect perioperative lung injury. The investigators will...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

National Heart, Lung, and Blood Institute (NHLBI)

Clinicaltrials.gov

Meditative Movement for COPD Symptoms in Non-Smoking Flight Attendants

This study will explore the a Qigong based exercise intervention, here referred to as Meditative Movement (MM), to ameliorate the symptoms associated with chronic obstructive pulmonary disease (COPD) and its...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Norris Cotton Cancer Center

Clinicaltrials.gov

Pivotal Study to Assess the Efficacy, Safety and Tolerability of...

Primary Objective: To evaluate the efficacy of dupilumab administered every 2 weeks in patients with moderate-or severe Chronic Obstructive Pulmonary Disease (COPD) as measured by - Annualized rate of acute...

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

Regeneron Pharmaceuticals

Clinicaltrials.gov

Tezepelumab COPD Exacerbation Study

A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 2a Study to Explore the Efficacy and Safety of Tezepelumab in Adults with Moderate to Very Severe Chronic Obstructive...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

Amgen

Treatments Today

Many current treatments for chronic obstructive pulmonary disease (COPD) alleviate symptoms through bronchodilators, which relax the muscles around the airways.

Prescription treatments on the market in 2019.

Azithromycin

Azithromycin prevents exacerbations of COPD (acute bronchitis, pneumonia and influenza), but it isn't clear whether this is due to its antibiotic effect or its anti-inflammatory properties.

Availablity

Brands

Azasite, Azithromycin 3 Day Dose Pack, Azithromycin 5 Day Dose Pack, Zithromax, Zithromax TRI-PAK, Zithromax Z-Pak, Zmax

Drug Class

Macrolide Antibiotics

Generic

Azithromycin

mayoclinic.org

Albuterol

Albuterol is a bronchodilator used to prevent and treat wheezing, difficulty breathing, chest tightness, and coughing caused by lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). Albuterol relaxes and opens the air passages to the lungs to make breathing easier. Albuterol belongs to class of drugs called short-acting beta-2- agonist bronchodilators. Available in different formulations, including oral syrups, inhalation powders, inhalation suspensions, and inhalation solutions.

Availablity

Brands

ProAir HFA, ProAir RespiClick, Proventil HFA, Ventolin HFA, AccuNeb

Drug Class

Short-acting Beta2-agonists (Bronchodilators)

Generic

Albuterol

medlineplus.gov

Inhaled combination of Indacaterol and Glycopyrrolate

Utibron Neohaler, a combination medicine containing glycopyrrolate and indacaterol, is used to prevent airflow obstruction or bronchospasm in people with COPD. Glycopyrrolate is an anticholinergic. Indacaterol is a bronchodilator. These medications work by relaxing muscles in the airways to improve breathing. Utibron Neohaler should not be used in patients with asthma. Indacaterol may increase the risk of death in people with asthma, but the risk in people with COPD is not known.

Availablity

Brands

Utibron Neohaler

Drug Class

Combination Inhaled Medicine: Beta2 Agonist + Anticholinergic

Generic

Glycopyrrolate and Indacaterol (Inhalation)

drugs.com

Inhaled Indacaterol

Inhaled indacaterol is a bronchodilator used to control wheezing, shortness of breath, coughing, and chest tightness caused by COPD. It works by relaxing and opening air passages in the lungs, making it easier to breathe. Indacaterol belongs to class of drugs called long-acting beta-2- agonists. It's available in a 75 mcg capsule.

Availablity

Brands

Arcapta Neohaler

Drug Class

Long-acting Beta2-agonists (Bronchodilators)

Generic

Indacaterol

medlineplus.gov

Inhaled Ipratropium Bromide

Inhaled ipratropium is a bronchodilator used to prevent wheezing, shortness of breath, coughing, and chest tightness in COPD patients. It works by relaxing and opening air passages in the lungs, making it easier to breathe. Ipratropium belongs to a class of medications called short-acting anticholinergics.

Availablity

Brands

Atrovent, Atrovent HFA

Drug Class

Short-acting Anticholinergics (Bronchodilators)

Generic

Ipratropium inhalation

mayoclinic.org

Roflumilast

Roflumilast is used in people with severe COPD to reduce the number of episodes or worsening of COPD symptoms. The drug works by decreasing inflammation (swelling) in the lungs. Roflumilast belongs to a class of drugs called phosphodiesterase inhibitors..

Availablity

Brands

Daliresp

Drug Class

Phosphodiesterase-4 Inhibitors

Generic

Roflumilast

mayoclinic.org

Theophylline

Theophylline is used to prevent and treat wheezing, shortness of breath, and chest tightness caused by asthma, chronic bronchitis, emphysema, and other lung diseases. It relaxes and opens air passages in the lungs, making it easier to breathe.

Availablity

Brands

Aerolate III, JR, and SR, Bronkodyl, Elixophyllin, Quibron-T/SR, Respbid, Slo-Bid Gyrocaps, Slo-Phyllin, T-Phyl, Theo-24, Theo-Dur, Theo-Time, Theo-X, Theobid, Theochron, Theoclear LA-130, Theoclear LA-260, Theolair, Theolair-SR, Theovent, Uni-Dur, Uniphyl

Drug Class

Methylxanthines

Generic

Theophylline

medlineplus.gov

Tiotropium

Tiotropium is a bronchodilator used to prevent wheezing, shortness of breath, coughing, and chest tightness in COPD patients. It works by relaxing and opening air passages in the lungs, making it easier to breathe. Tiatropium belongs to a class of medications called long-acting anticholinergics.

Availablity

Brands

Spiriva, Spiriva Respimat, Spiriva HandiHaler, Spiriva Respimat 30 Dose, Spiriva Respimat 14 Dose, Spiriva Respimat 28 ACT, Spiriva Respimat 60 ACT

Drug Class

Long-acting Anticholinergics (Bronchodilators)

Generic

Tiotropium inhalation

mayoclinic.org

From the latest relevant research and COPD expert interviews to personal stories and advice on managing your symptoms, here’s everything about COPD that’s making headlines.

Pulmonology Advisor

Treatment Failure in COPD Reduced

Treatment failure may be significantly reduced by a 3-month course of azithromycin for acute chronic obstructive pulmonary disease (COPD) exacerbations that require hospitalization.

Learn More

Vancouver Sun

Inhaled steroids reduce risk of lung cancer in COPD patients: UBC study

Patients with chronic obstructive pulmonary disorder (COPD) who used inhaled steroids for their breathing problems had a 30 per cent reduced risk of getting lung cancer, according to a study by University of B.C. researchers.

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Medpage Today

Poor Sleep May Increase COPD Exacerbation Risk

Poor sleep quality, assessed using a validated sleep questionnaire, was associated with higher COPD exacerbation risk over 18 months of follow-up in a Canadian prospective cohort study.

Learn More

WebMD

Daily Aspirin Might Ease COPD Flare-Ups

MONDAY, March 4, 2019 (HealthDay News) -- Many Americans take a daily low-dose aspirin to protect their hearts. Now it appears aspirin may also reduce flare-ups of chronic obstructive pulmonary disease (COPD).

Learn More

WebMD

COPD May Strike Women Harder Than Men

WEDNESDAY, May 22, 2019 (HealthDay News) -- Women with chronic obstructive pulmonary disease (COPD) appear to have a harder time than men with the progressive lung disorder, a new study suggests.

Learn More

WebMD

Is Daily Vitamin D a Lifesaver for COPD Patients?

FRIDAY, Jan. 11, 2019 (HealthDay News) -- Deadly lung attacks may be averted in some COPD patients with a daily dose of vitamin D, new research suggests.

Learn More

Whether you’re considering participating in a clinical trial or just looking for more information about COPD, we want to keep you informed about living with COPD, your treatment options, and the clinical trial process.