Type 2 Diabetes?

Discover new study treatments by joining a clinical trial.

Type 2 diabetes is a chronic condition that impacts the way your body uses insulin. Treatment might involve lifestyle changes plus one or more oral or injectable medications. We’re investigating new study treatment options for diabetes — help us change the future of your condition by joining our clinical trial.

10.5%

of the U.S. population have diabetes. ¹

1.5 million

new cases of diabetes were diagnosed in U.S. adults aged 18 or older in 2018. ¹

7th

Diabetes was the seventh leading cause of death in the United States in 2017. ¹

Those that don’t have diabetes take it for granted. This disease controls your whole life.”

TrialSpark interview with type 2 diabetes patient - December 2019

Those that don’t have diabetes take it for granted. This disease controls your whole life.”

TrialSpark interview with type 2 diabetes patient - December 2019

Type 2 Diabetes Clinical Trials

Learn about the newest diabetes study treatments now being investigated, including cutting-edge options available to clinical trial participants.

TrialSpark is now recruiting for a trial that tests the effectiveness of a study treatment for type 2 diabetes.

Learn more

Clinicaltrials.gov

Education and Exercise Program for Adults With Type 2 Diabetes

The purpose of this two phase study is to: 1) develop and 2) assess a program titled: Merging Yoga, Occupational Therapy and Nutrition Education (MY-OT-Ed) designed for low income adults with Type 2 Diabetes....

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

American Occupational Therapy Foundation

Clinicaltrials.gov

Food and Education Effects on Diabetes Study

Low-income adults are disproportionately affected by diabetes, experiencing greater rates of diabetes, diabetes-related complications, and mortality. Dietary habits play an important role in achieving and...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

France-Merrick Foundation

Clinicaltrials.gov

Pulsatile Insulin Infusion Therapy in Patients With Type 1 and Type 2...

This study is an open label, prospective, randomised comparative, single center study. In the present study, the impact of a 12-week pulsatile insulin infusion therapy (PIT) with Humulin R 100 from

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

Innovative Diabetes Treatment Studies LLC.

Clinicaltrials.gov

Diabetes Prevention Programming for Women With a History of...

The purpose of this study is to offer women with a history of gestational diabetes access to diabetes prevention programming; their children 10 and older can participate.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Indiana University

Clinicaltrials.gov

Dexcom G6 Intervention Study

The study will assess if Continuous Glucose Monitoring (CGM) represents a better tool to guide healthcare providers in adjusting insulin therapy, by providing a more complete 24-hour assessment of glucose...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Emory University

Clinicaltrials.gov

Tailored Home-Based Exercise Program for Multiple Chronic Conditions

A home-based, tailored, technology-enhanced home-based exercise program (iHBE) using a combination of the integrated mobile technologies (wearable device and phone application) and tailored home-based exercise...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Institute of Nursing Research (NINR)

Clinicaltrials.gov

Impact of Metabolic Health on Sperm Epigenetic Marks in Humans

This study is designed to evaluate whether epigenetic markers in overweight men with type 1 or type 2 diabetes can be improved with a 3 month lifestyle intervention program.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Joslin Diabetes Center

Clinicaltrials.gov

Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and...

The investigators aim to determine the effect of suvorexant on subjective total sleep time (TST) in suboptimally controlled Type 2 diabetics with chronic insomnia in a randomized placebo-controlled trial for 3...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

Massachusetts General Hospital

Clinicaltrials.gov

Combining Flash Glucose Monitoring and Online Peer Support to Improve...

Currently, Hispanic Spanish-speaking individuals are not receiving culturally appropriate diabetes care. Lack of knowledge impacts several areas of type 2 diabetes (T2D) management, including healthy eating...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

La Trobe University

Clinicaltrials.gov

(R33 Phase) Delish Study: Diabetes Education to Lower Insulin,...

We plan an R33 phase trial in which 120 persons with type 2 diabetes (T2DM) will be randomized (using a 1:1 ratio) to education alone (Ed) on following a carbohydrate restricted diet for T2DM, or this same...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Center for Complementary and Integrative Health (NCCIH)

Clinicaltrials.gov

Understanding the Cardiovascular Benefits of the Anti-Diabetes...

To examine the effect of an increase in plasma beta-hydroxy-butyrate (B-OH-B) levels, spanning the physiologic and pharmacologic range (+0.5, +2.0, and +5.0 mmol/L), on: (i) parameters of left ventricular (LV)...

Trial Type

Interventional

Trial Phase

Phase 1

Sponsorship

The University of Texas Health Science Center at San Antonio

Clinicaltrials.gov

Clinic to Community Navigation to Improve Diabetes Outcomes

Background and justification: Nearly 29 million Americans (9.3% of the population) have type 2 Diabetes Mellitus (T2DM) and another 86 million are considered prediabetic, 20-30% of whom will develop diabetes...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Nancy Schoenberg

Clinicaltrials.gov

Recurrent Hypoglycemia in Type 1 Diabetes (Aim 1)

This study will explore the cerebral mechanisms of impaired awareness of hypoglycemia (IAH) in type 1 diabetics following exposure to experimental recurrent hypoglycemia (HG). To induce IAH, patients with T1D...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

University of Minnesota

Clinicaltrials.gov

Motion Perception in Individuals With Type 2 Diabetes

Is the ability to perceive motion altered by diabetes? The investigators are measuring motion perception using a technique called vestibular thresholds. Subjects will undergo 3 hours of testing in which they...

Trial Type

Observational

Sponsorship

Massachusetts Eye and Ear Infirmary

Clinicaltrials.gov

PRECISION Study: Evaluating the Accuracy of the LabPatch Continuous...

The purpose of this study is to evaluate the accuracy and efficacy of the Cambridge Medical Technologies, LLC LabPatch Continuous Glucose Monitoring (CGM) System compared to a laboratory glucose analyzer (YSI...

Trial Type

Observational

Sponsorship

Cambridge Medical Technologies, LLC

Clinicaltrials.gov

Dulce Digital-Me: An Adaptive mHealth Intervention for Underserved...

This study will compare Dulce Digital (i.e., the investigators' proven-effective combination of "one-size-fits-all" educational text messages and nurse monitoring of patient-transmitted blood glucose values)...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

San Diego State University

Clinicaltrials.gov

Validation of Machine Learning Based Personalized Nutrition Algorithm...

This is an initial validation study of the Personal Nutrition Project (PNP) algorithm in a North American population with recently diagnosed Type 2 Diabetes (T2D). This is a 2-stage, single-group feeding study...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

NYU Langone Health

Clinicaltrials.gov

Texting for Diabetes

Diabetes is a common complication of pregnancy that increases risks for both the mother and baby. Poorly controlled diabetes has been associated with very large babies, congenital heart defects, stillbirth,...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

St. Louis University

Clinicaltrials.gov

Insulin Degludec for the Management of Patient With Recurrent...

Given the longer half life of insulin degludec compared to glargine /levemir ,investigators believe that insulin degludec will reduce the rate of recurrent DKA. The investigator will randomize participants to...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Hennepin Healthcare Research Institute.

Clinicaltrials.gov

Role of Canagliflozin on CD34+ Cells in Patients With Type 2 Diabetes

The investigators hypothesize that Cana may be able to improve number and function of CD34+ endothelial progenitor cells. The investigators also propose that this expected cardiovascular benefit is independent...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

Janssen Scientific Affairs, LLC

Clinicaltrials.gov

Pancreatic Islet Transplantation Into the Anterior Chamber of the Eye

The treatment in this trial consists of intraocular islet transplantation. A single dose of 1000 - 2000 Islet Equivalents (IEQ)/kg recipient body weight (BW) will be infused into the anterior chamber of the...

Trial Type

Interventional

Trial Phase

Phase 1/Phase 2

Sponsorship

Bascom Palmer Eye Institute

Clinicaltrials.gov

Nitrate Supplementation and Exercise Tolerance in Patients With Type...

The purpose of this study is to use a randomized, double-blind, placebo controlled study design to comprehensively investigate the impact of 8-weeks of dietary nitrate supplementation on skeletal muscle blood...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

American Diabetes Association

Clinicaltrials.gov

Health Literacy Intervention to Improve Diabetes Outcomes Among Rural...

The researchers will conduct a patient-randomized, pragmatic clinical trial among 6 rural PCMHs in Arkansas, targeting individuals with uncontrolled type 2 diabetes. The primary aims are to: 1. test the...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Clinicaltrials.gov

The Relationship Between Advanced Glycation Endproducts and Diabetes

The overall purpose of this COMIRB application is to perform a cross-sectional pilot study to aid in the design of a prospective epidemiologic study for an NIH grant application. The long term goal of this...

Trial Type

Observational

Sponsorship

University of Colorado, Denver

Clinicaltrials.gov

Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and...

Diabetes type two is a debilitating disease that leads to chronic morbidity such as accelerated microvascular disease. Accelerated microvascular disease may produce blindness, end stage renal disease,...

Trial Type

Observational

Sponsorship

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Clinicaltrials.gov

Efficacy and Safety of Efpeglenatide Versus Placebo in Patients With...

Primary Objective: To demonstrate the superiority of once weekly injection of efpeglenatide in comparison to placebo in glycated hemoglobin (HbA1c) change in participants with type 2 diabetes mellitus (T2DM)...

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

Sanofi

Clinicaltrials.gov

Multicenter Assessment of the Pancreas in Type 1 Diabetes

The overall goal of this research is to develop and validate standard operating procedures (SOP) to assess the human pancreas in individuals with type 1 diabetes (T1D) and other forms of diabetes using...

Trial Type

Observational

Sponsorship

Juvenile Diabetes Research Foundation

Clinicaltrials.gov

Resilience-Based Diabetes Self-Management Education (RB-DSME) for...

African Americans are twice as likely to have type 2 diabetes as non-Hispanic Whites and are less likely to engage in effective diabetes self-management. There is a critical need for intensive lifestyle...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

University of Colorado, Aurora

Clinicaltrials.gov

Hospital Workplace Nutrition Study

The purpose of this study is to evaluate the effects of a plant-based diet on body weight, blood pressure, and plasma lipid concentrations, as part of a hospital workplace program.

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Sibley Memorial Hospital

Clinicaltrials.gov

Home-based Diabetes-Modified Behavioral Activation Treatment for Low...

The objective of this protocol is to evaluate the efficacy and cost-effectiveness of 8 sessions of in-home, group-based, culturally-modified, manualized diabetes-modified, behavioral activation treatment (Home...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Medical College of Wisconsin

Clinicaltrials.gov

Control:Diabetes Pilot Study I

This is a single arm open label pilot clinical trial that will assess patient-reported blood glucose levels before and after using the Control:Diabetes mobile app, while collecting user feedback and...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Brigham and Women's Hospital

Clinicaltrials.gov

Impact of Semaglutide on CD34+ EPC and Fat Derived MSC

The Investigator is trying to ascertain whether an FDA approved medication of T2DM, Semaglutide, can improve the number, function and gene expression of subjects CD34+ endothelial progenitor cells. EPCs are...

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

Sabyasachi Sen

Clinicaltrials.gov

Acute Study of Effect of Ultrasound Vagus Nerve Stimulation on...

This is an early feasibility study to evaluate the proof of concept of modulation of glycemia by non-invasive ultrasound vagus nerve stimulation. This protocol is exploratory in nature, therefore it is not...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

STATKING Clinical Services

Clinicaltrials.gov

Impact of App Based Diabetes Training Program in Conjunction With the...

This is a multi-center, open-label, parallel-group, randomized controlled study in subjects with type 2 diabetes using multiple daily injection (MDI) insulin therapy. Subjects will be randomized to either...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Becton, Dickinson and Company

Clinicaltrials.gov

Post-prandial Effects of Extra Virgin Olive Oil on Endothelial...

Purpose: The number of cases of adults with Type 2 diabetes has quadrupled since 1980. This increase in the number of cases of diabetes is attributed to changes in dietary patterns, which include an increase...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Griffin Hospital

Clinicaltrials.gov

DHS MIND Metabolomics

The study team will evaluate whether metabolomic signatures of neurocognitive decline trajectories are exacerbated by the presence of type 2 diabetes mellitus (T2D) and whether these signatures contribute in...

Trial Type

Observational

Sponsorship

National Institute on Aging (NIA)

Clinicaltrials.gov

Almond Butter and Fasting Glucose

A two-period randomized crossover study will be conducted to determine the effect of almond butter as an evening snack on fasting blood glucose in adults with type 2 diabetes, not taking insulin.

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

Penn State University

Clinicaltrials.gov

Advanced Glycation Endproducts and Bone Material Strength in T2D...

The purpose of this study is to determine if a specific form of Vitamin B known as Pyridoxamine helps improve bone strength over one year in women (>65 yrs old) with Type 2 Diabetes. The investigators know...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Columbia University

Clinicaltrials.gov

Stories for Change: Digital Storytelling for Diabetes Self-Management...

Hispanic adults are twice as likely to have type 2 diabetes mellitus (T2D) and 1.5 times more likely to die from the disease than non-Hispanic whites. These disparities are mediated, in part, by less healthful...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Clinicaltrials.gov

IDegLira HIGH Trial

Basal-bolus insulin therapy is recommended for patients with poorly controlled type 2 diabetes (T2D) and HbA1c >9%. However, basal-bolus insulin is labor intensive and associated with increased risk of...

Trial Type

Interventional

Trial Phase

Phase 3

Sponsorship

Novo Nordisk A/S

Clinicaltrials.gov

Cognitive Behavioral Therapy for African Americans With Uncontrolled...

The main purpose of the study is to assess the feasibility and acceptability of a Culturally-Tailored Cognitive Behavior intervention (CT-CB) for African American patients with uncontrolled Type 2 diabetes....

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Clinicaltrials.gov

Comparative Effectiveness of Diabetes Shared Medical Appointment...

In this study, the investigators will compare the effectiveness of patient-driven diabetes Shared Medical Appointments (SMAs) to standardized diabetes SMAs. The curriculum to be used is Targeted Training for...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

Patient-Centered Outcomes Research Institute

Clinicaltrials.gov

Pilot: Insulin Sensitivity/Management in Hyperglycemic Patients in...

This study is for people with diabetes who have either healthy kidneys or who have end stage renal disease (ESRD) and are on hemodialysis that are having surgery. This research will help increase our knowledge...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

State University of New York - Downstate Medical Center

Clinicaltrials.gov

Return of First-phase Insulin Secretion in Type 2 Diabetes is...

The hypothesis for this study is that pancreas lipid will be more closely associated with first-phase beta-cell response in African-Americans than in European-Americans, both at baseline and in response to...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

University of Alabama at Birmingham

Clinicaltrials.gov

Self-efficacy, Beliefs and Adherence- Pilot and Feasibility Trial of...

This study uses an intervention mixed methods design. The overall purpose is to improve medication adherence and assess the clinical impact on diabetes outcomes among patients with uncontrolled diabetes. We...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

William S. Middleton Memorial Veterans Hospital

Clinicaltrials.gov

Continuous Monitoring and Control of Hypoglycemia

Evaluate safety of non-adjunctive CGM use in CGM naive participants.

Trial Type

Observational

Sponsorship

DexCom, Inc.

Clinicaltrials.gov

The Impact of Diabetes on REvascularization

The presence of foot symptoms at rest or tissue necrosis in patients with peripheral artery disease is a medical urgency and represents a state of critical limb ischemia (CLI) where the risk of amputation, in...

Trial Type

Observational

Sponsorship

Massachusetts General Hospital

Clinicaltrials.gov

Effect of Dapagliflozin on Hepatic and Renal Glucose Metabolism...

Researchers hope to determine the organ (liver and/or kidney) responsible for the increase in endogenous glucose production (EGP) following the induction of glucosuria (when glucose is excreted in detectable...

Trial Type

Interventional

Trial Phase

Phase 4

Sponsorship

AstraZeneca

Clinicaltrials.gov

Women in Control: A Virtual World Study of Diabetes Self-Management

This study evaluates the comparative effectiveness of a diabetes self management (DSM) group medical visit in the virtual world (Second life) verses a face-to-face format, aimed to increase physical activity...

Trial Type

Interventional

Trial Phase

N/A

Sponsorship

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Clinicaltrials.gov

Ketogenic Diet Treatment of Obesity With Co-morbid Type 2 Diabetes...

The purpose of the study is to evaluate the efficacy and safety of ketogenic diet (KD) treatment of (i) obesity, (ii) type 2 diabetes mellitus and (iii) obstructive sleep apnea (OSA) in patients with obesity...

Trial Type

Interventional

Trial Phase

Phase 2

Sponsorship

Mid-Atlantic Epilepsy and Sleep Center, LLC

Whether you’re considering participating in a clinical trial or just looking for more information about diabetes, we want you to keep you informed about living with diabetes, your treatment options, and the clinical trial process.