In a clinical trial, drug titration refers to the process of adjusting the dose of medication (the titrant) for maximum reduction of symptoms while avoiding as many side effects as possible. It may happen quickly or take a while. The purpose is to find the perfect balance of a particular medication for a patient. Dose titration refers to titrating to the maximum tolerated dose, and the titration curve is a graphical representation of a drug’s therapeutic effect versus adverse effects as dosage increases.