OTIS Vedolizumab Pregnancy Exposure Registry

A new Crohn's investigational drug called Etrolizumab

This is a multicenter, Phase 3, double-blind, placebo-controlled study evaluating the efficacy, safety, and tolerability of etrolizumab compared with placebo during induction and maintenance treatment of...

Clinicaltrials.gov

Oral Administration of MB-102 Versus Dual Sugar Testing for Gut...

The objectives of the study are to evaluate the safety and tolerability of oral administration of MB-102, and to evaluate the use of MB-102 as a means of measuring gut permeability in normal participants...

Clinicaltrials.gov

Long-term Safety With Vedolizumab Intravenous (IV) in Pediatric...

The purpose of this study is to determine the safety profile of long-term vedolizumab IV treatment in pediatric participants with UC or CD.

Clinicaltrials.gov

Contrast Enhanced Ultrasound in Human Crohn's Disease-Lumason

The investigators plan to compare contrast-enhanced ultrasound to CT and MRI for the detection and quantification of intestinal inflammation in the the setting of pediatric small bowel Crohns disease

Clinicaltrials.gov

Study to Assess Efficacy and Safety of Cx601, Adult Allogeneic...

The purpose of this study is to evaluate the combined remission of complex perianal fistulas, defined as the clinical assessment at Week 24 of closure of all treated external openings that were draining at...

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A Dietary Intervention Study on the Microbiome in Crohn's Disease...

This protocol is designed to compare the effectiveness of a dietary intervention for 7 days, given to patients with Crohn's disease (CD) in remission: a soy-based diet, which has been demonstrated to have...

Clinicaltrials.gov

Efficacy and Safety of Oral OPS-2071 in Subjects With Crohn's Disease...

The purpose of this study is the effects, safety and how OPS-2071 (150, 300, or 600 mg twice a day [BID]) is as an add-on therapy in Crohn's disease who show symptoms of active inflammation despite being on...

Clinicaltrials.gov

Pilot Study of Fundamental Modification of the Gut Microbiota in the...

The purpose of this study is to determine the effect of a novel gut microbiota-targeted therapeutic regimen (bowel lavage and antibiotics with or without an antifungal) in the management of active Crohn's...

Clinicaltrials.gov

Vedolizumab Subcutaneous Long-Term Open-Label Extension Study

The purpose of this study is to obtain long term safety and tolerability data of vedolizumab subcutaneous (vedolizumab SC) in participants with ulcerative colitis (UC) and Crohn's disease (CD).

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Autologous Stem Cell Transplantation for Crohn's Disease

The objective of this study is to evaluate the safety and effectiveness of administering high-dose chemotherapy followed by infusion of autologous CD34-selected peripheral blood stem cells (PBSC) in pediatric...

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Triple Combination Therapy in High Risk Crohn's Disease (CD)

The purpose of this study is to determine the effect of triple combination therapy with an anti-integrin (vedolizumab intravenous [IV]), a tumor necrosis factor (TNF) antagonist (adalimumab subcutaneously...

Clinicaltrials.gov

Precision Crohn's Disease Management Utilizing Predictive Protein...

Crohn's disease and ulcerative colitis affect about 1.6 to 3 million people in the United States with many of those being young children and adolescents. Physicians need better ways to inform decisions on...

Clinicaltrials.gov

Safety and Efficacy of EcoActive on Intestinal Adherent Invasive E....

This study will evaluate the safety of oral administration of EcoActive to patients with inactive Crohn's disease and how it affects the levels of AIEC in stool.

Clinicaltrials.gov

Intralipid Versus SMOFlipid in HPN Patients

This study will randomize all patients who are new to the Mayo Clinic HPN team to either standard lipid emulsion (Intralipid) or SMOFLipid.

Clinicaltrials.gov

Diet as Essential Therapy (DIET) for Inflammatory Bowel Disease

Recent data suggest that diet in inflammatory bowel disease (IBD) may lead to both symptom control and disease remission. Historically certain diets have been recommended for patients with Crohn's disease...

Clinicaltrials.gov

Early MRI Prediction of Crohns

The investigators plan a prospective study designed to optimize and translate noncontrast, novel Magnetic Resonance Imaging (MRI) techniques for detecting and measuring intestinal inflammation as well as for...

Clinicaltrials.gov

Efficacy and Safety of TD-1473 in Crohn's Disease

A Phase 2 study to evaluate the efficacy, safety and tolerability of TD-1473 in subjects with moderately-to-severely active Crohn's Disease with up to 48 weeks of treatment.

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Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease

This research study will evaluate if specific blood, stool and MRI tests can tell the difference between bowel wall inflammation without scarring and bowel wall inflammation with scarring that can cause bowel...

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Myoelectric GutPrint-Crohn's Disease

A feasibility study for assessing and recording myoelectric activity in patients for early detection of flare in patients with Crohn's disease and differentiating the myoelectric signals from Crohn's disease...

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Reverse Engineering of Exclusive Enteral Nutrition

Primary: Nutritional therapy in the form of a whole-food based smoothie can be used to induce remission of active Crohn's disease. Secondary: Consuming a whole foods based smoothie will result in measurable...

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Autologous Stem Cell Transplant for Crohn's Disease

Crohn's Disease (CD) is an inflammatory bowel disease. It can lead to significant complications and discomfort in the stomach and intestines. Crohn's disease is a debilitating, incurable disease of immune...

Clinicaltrials.gov

High Dose Interval Vitamin D Supplementation in Patients With IBD...

The goal of this study will be to assess the safety and efficacy of high-dose interval Vitamin D3 therapy in children and young adults with Inflammatory Bowel Disease being treated with serial Remicade...

Clinicaltrials.gov

A Six Week Efficacy, Safety and Tolerability Study of V565 in Crohn's...

The purpose of this study is to evaluate the efficacy and safety of V565 in participants with active Crohn's Disease.

Clinicaltrials.gov

A Study to Evaluate Efficacy and Safety of Ustekinumab Re-induction...

The primary purpose of this study is to evaluate the efficacy and safety of a single intravenous (IV) re-induction dose of approximately 6 milligram per kilogram (mg/kg) ustekinumab in participants with...

Clinicaltrials.gov

Treatment of Perianal Disease Using Adipose-derived Stem Cells

This study will compare healing and surgical outcomes in patients with chronic perianal disease treated with Adipose-derived Stem Cells (ASCs) to outcomes in patients treated in traditional surgical techniques...

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Effect of SB CD on Chylomicron

It is often suggested that lymphatic vessels are ineffective in transporting cargo in Crohn's disease. Our own work on surgically resected tissue supports this concept (1), but the concept has not been...

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Pediatric MSC-AFP Sub-study for Crohn's Fistula

The purpose of this study is to determine the safety of using an autologous mesenchymal stromal cell (MSC) coated fistula plug in people with fistulizing Crohn's disease. Autologous means these cells to coat...

Clinicaltrials.gov

Study of the Kono-S Anastomosis Versus the Side-to-side Functional...

This study proposes a randomized prospective study comparing the Kono-S anastomosis to the standard side-to-side anastomosis.This will be a multi-center randomized prospective trial. Patients with Crohn's...

Clinicaltrials.gov

Safety and Tolerability of Vorinostat for the Treatment of...

Background: Crohn's disease (CD) is an inflammatory bowel disease. It causes inflammation of the gut. Symptoms may include diarrhea, abdominal pain, fatigue, weight loss and malnutrition. CD has no cure, but...

Clinicaltrials.gov

Vedolizumab Post Op Study

This is a pilot study that will determine the endoscopic recurrence of Crohn's disease 12 months after curative, resective ileal or ileocolonic surgery in patients receiving post-operative vedolizumab...

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Stelara and Tremfya Pregnancy Exposure Registry OTIS Autoimmune...

The purpose of the OTIS Autoimmune Diseases in Pregnancy Study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications...

Clinicaltrials.gov

A Study of the Efficacy and Safety of Guselkumab in Participants With...

The purpose of this program is to evaluate the efficacy and safety of guselkumab in participants with Crohn's disease.