High Dose Interval Vitamin D Supplementation in Patients With IBD Receiving Remicade

A new Crohn's investigational drug called Etrolizumab

This is a multicenter, Phase 3, double-blind, placebo-controlled study evaluating the efficacy, safety, and tolerability of etrolizumab compared with placebo during induction and maintenance treatment of...

A new asthma drug candidate called fevipiprant

The overall purpose of this study is to determine the efficacy of fevipiprant (dose 1 and dose 2 once daily), compared with placebo, as add-on to standard-of-care asthma therapy, in terms of avoidance of...

Clinicaltrials.gov

Docosahexaenoic Acid (DHA) Supplementation in High Risk Pregnancies

Purpose: Determine the effects of maternal docosahexaenoic acid (DHA) supplementation during pregnancy on levels of DHA, synaptamide (novel anti-inflammatory metabolite), and inflammatory biomarkers during...

Clinicaltrials.gov

RBN-2397, an Oral PARP7 Inhibitor, in Patients With Solid Tumors ,...

RBN-2397 inhibits PARP7, an enzyme that is switched on by cancer stresses, such as the toxins in cigarette smoke. Cancer cells use PARP7 to hide from the immune system by stopping the cell from sending a...

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Augmented Mindfulness for Resilience in Early Life

This project aims to determine whether neurofeedback augmented mindfulness intervention increases the plasticity in brain areas affected by exposure to early life adversity in youth. The study will first...

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Respiratory-Gated Vagal Nerve Stimulation for Chronic Pain

Vagus Nerve Stimulation (VNS) is a validated and FDA-approved therapy that has improved the lives of many individuals with epilepsy and depression and has shown promise for treating chronic pain. However,...

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Extension of Phase 3 Gene Therapy for Painful Diabetic Neuropathy

The purpose of this study is explore the overall safety profile and durability of efficacy of VM202 in painful diabetic peripheral neuropathy. All subjects still in follow-up for the VMDN-003 study or who have...

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Targeted Noninvasive Brain Stimulation to Improve Hand Dexterity in...

This study will investigate the use of High-definition Transcranial Direct Current Stimulation (HD-tDCS) in the functional improvement of hand dexterity while performing music-assisted hand exercises.

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Noninvasive Evaluation for Carotid Artery Stenosis: The Carotid...

The purpose of this study is to determine the accuracy of a new non-invasive device, the Carotid Stenotic Scan (CSS), to check for stenosis of the internal carotid artery (ICA) as compared to a carotid duplex...

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tSCI Contrast Enhanced Ultrasound Study

Patients with traumatic spinal cord injury (tSCI) often suffer from spinal cord swelling inside the thecal sac, which contains the spinal cord and surrounding fluid, leading to increased pressure on the spinal...

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Lofexidine for Management of Opioid Withdrawal With XR-NTX Treatment

This is an open-label pilot trial to evaluate the safety and tolerability of lofexidine in the management of opioid withdrawal symptoms while initiating outpatient treatment with naltrexone. The initiation...

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Strategy Based Technique to Enhance Memory (STEM) for Improving New...

The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons with a Traumatic Brian Injury (TBI). The study is designed to research how well this...

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Respiratory Muscle Training Before Surgery in Preventing Lung...

This phase II trial studies how well respiratory muscle training before surgery works in preventing lung complications after surgery in patients with stage I-IIIB lung cancer. Patients with lung cancer who...

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Virtual Visits to Optimize Research Trial Offerings to HF Patients

This pilot study seeks to understand if distance health technology with virtual visits hold the key to improving access for patients who wish to partake in clinical trials clearing barriers to enrollment.

Clinicaltrials.gov

Persistent Postpartum Cardiovascular Dysfunction in Patients With...

The investigators plan to enroll women with PE prospectively to evaluate incremental cardiovascular risk in those who have PE with severe features. This study includes detailed echocardiographic evaluation at...

Clinicaltrials.gov

Video Education for Prenatal Testing Choices

The purpose of the investigator's study is to assess the effect of a standardized prenatal testing educational video on the use of prenatal genetic testing and decision-making.

Clinicaltrials.gov

Everolimus Monotherapy as Immunosuppression After Liver Transplant

Tacrolimus is the standard immunosuppressive drug used to prevent organ rejection post liver transplant. One side effect of Tacrolimus is nephrotoxicity. Everolimus does not have the nephrotoxicity side...

Clinicaltrials.gov

Intermittent Pneumatic Compression Device for Vein Dilation in Kidney...

This is a single center pilot study that is seeking to determine whether the use of the Fist Assist® device for 360 hours over 90 days by patients with advanced CKD prior to AVF surgery results in significant...

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Arm Training in Standing After Stroke

This study will examine the feasibility of providing task-oriented arm training in standing or during walking in individuals with movement deficits due to stroke. Participants will received 24 sessions of arm...

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Ultra Low Dose Radiation Delivered Before or After Chemotherapy-Free...

This phase II trial studies how well ultra low dose radiation works before or after chemotherapy-free targeted therapy in treating patients with mantle cell lymphoma that has come back or does not respond to...

Clinicaltrials.gov

CXA-10 Study in Subjects With Pulmonary Arterial Hypertension

This is a Phase 2, multicenter, open-label extension (OLE) of study CXA-10-301, to evaluate the long term safety and efficacy of daily dosing of CXA-10.

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Evidence-Based Interventions to Enhance Outcomes Among Struggling...

Despite decades of research on reading disabilities, little is known about improving reading in the middle grades (i.e., grades 3-6) and advancements have been hindered by the narrow focus on reading problems...

Clinicaltrials.gov

Project REST: Regulation of Eating and Sleep Topography

Overweight/obesity and inadequate sleep are prevalent, and frequently co-occurring, health risks among children, both of which are associated with serious medical and psychosocial health complications...

Clinicaltrials.gov

Netarsudil Use After Descemetorhexis Without Endothelial Keratoplasty

Primary aim of the study is to determine whether a rho kinase inhibitor, Netarsudil, can speed corneal clearance after DWEK. Secondary aim of the study is to investigate whether patient factors, such as...

Clinicaltrials.gov

Reducing Health Disparities in Childhood Obesity

In this study, we will address cost barriers to participating in summer programs and hypothesize this will lead to marked improvements in children's obesogenic behaviors and a reduction in excessive, unhealthy...

Clinicaltrials.gov

Effectiveness of Chest Compressions Under Mild Hypoxia

The purpose of this study is to evaluate the effect of breathing a slightly reduced amount of oxygen will have on a rescuer's ability to provide chest compressions during CPR.

Clinicaltrials.gov

Comparison of Lithotripsy Urolithiasis Machines

A comparison on the outcomes of patients undergoing shockwave lithotripsy using the Storz machine versus the Dornier machine.

Clinicaltrials.gov

Mechanisms of Exercise Intolerance in Heart Failure With Preserved...

The global objective of this study is to determine the mechanisms of exercise intolerance and dyspnea on exertion (DOE) in patients with HFpEF and based on this pathophysiology, test whether specific exercise...

Clinicaltrials.gov

CALM IVF (Creating Affiliations, Learning, and Mindfulness for In...

The investigators have designed a psychoeducational group curriculum specifically for new in vitro fertilization (IVF) patients (both male and female) to improve their treatment knowledge, to allow them to...

Clinicaltrials.gov

Emotion Regulation Therapy for Clinical Worry and Rumination

The present project aims to broaden our understanding of neural mechanisms which may underlie change in symptoms occurring over the course of Emotion Regulation Therapy. Specifically, we aim to examine neural...

Clinicaltrials.gov

Remote Patient Monitoring in Pediatric Obesity

The goal of this study is to examine the feasibility and efficacy of a remote patient monitoring system for children who are obese.

Clinicaltrials.gov

Pitocin or Oral Misoprostol for PROM IOL

Premature rupture of membranes (PROM) is a common occurrence of pregnancies at term. A delay from PROM to labor is associated with an increased risk of intrauterine infection and associated maternal and fetal...

Clinicaltrials.gov

Diet, Physical Activity, and Sleep Habits

This study aims to observe if consistency in a young adult's schedule is related to health factors and outcomes, such as diet quality, amount of physical activity and sleep, and weight.

Clinicaltrials.gov

A Study of Combination Spartalizumab and Canakinumab in Patients With...

Primary Objective: - To confirm the safety and feasibility of canakinumab and spartalizumab (PDR-001) administered using a standard dose / schedule in the neo-adjuvant setting in renal cell carcinoma Secondary...

Clinicaltrials.gov

Thirty Million Words-Early Childhood Educator (TMW-ECE)

The purpose of the proposed study is to determine the efficacy of an eight-module interactive, online multi-media professional development course on our target population: individuals over the age of 18, who...

Clinicaltrials.gov

A Non-Interventional Pilot Study to Explore the Role of Gut Flora in...

This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.

Clinicaltrials.gov

Filipino Family Health Initiative

The overall objective of this research is to test the effectiveness of a parenting program on Filipino parents living in Southern California. The sample will include 180 Filipino immigrant families, half of...

Clinicaltrials.gov

Cisplatin, Docetaxel, and Pembrolizumab in Treating Patients With...

This phase II trial studies how well cisplatin, docetaxel, and pembrolizumab work in treating patients with stage II-III laryngeal cancer. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in...

Clinicaltrials.gov

Intuitive Control of a Hybrid Prosthetic Leg During Ambulation

The objective of this research is to determine the clinical benefits of an innovative and lightweight powered leg controlled using our intent recognition framework in laboratory and community environments.

Clinicaltrials.gov

Optimizing a Mobile Mindfulness Intervention for ICU Survivors

This is a factorial experimental trial involving adult survivors of cardiorespiratory failure treated in intensive care units (ICUs) that is conceptualized as the Optimization Phase of a multiphase...

Clinicaltrials.gov

Prebiotic vs Probiotic in Multiple Sclerosis

This is a randomized crossover-designed study to explore the immunologic effects of Prebiotics, as opposed to direct supplementation with beneficial bacteria (Probiotics) in the immune system of patients with...

Clinicaltrials.gov

R-MPV Followed by Nivolumab in Older (≥65) Pts With Previously...

The primary objective of Stage 1 is to evaluate the safety of nivolumab consolidation after R-MPV induction chemotherapy in older subjects with previously untreated PCNSL in terms of a tolerated dose (based on...

Clinicaltrials.gov

Neoadjuvant Cabozantinib in Treating Patients With Locally Advanced...

This phase II clinical trial studies how well cabozantinib works in treating patients with kidney cancer before surgery. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed...

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Carepartner Collaborative Integrated Therapy in Sub-Acute Stroke

A novel, web-based carepartner focused intervention (CARE-CITE) is designed to foster problem solving and skill building while facilitating carepartner engagement during upper extremity functional activities...

Clinicaltrials.gov

The Management of Pilonidal Wounds With ACell MicroMatrix® and Cytal®...

A case series involving the concomitant use of MicroMatrix® and Cytal® Wound Matrix 2-Layer with standard of care negative pressure wound therapy (NPWT) during the management of pilonidal wound healing.

Clinicaltrials.gov

Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken)

This study will provide preliminary estimates of safety and efficacy of the NightWare digital therapeutic system (iPhone + Apple watch + proprietary application) for the treatment of nightmare disorder...

Clinicaltrials.gov

Novel Guidance Device for Image Fusion and Needle Guidance in Lung,...

This study investigates whether a new image fusion technology can reduce patient radiation dose from CTs and/or procedure time during biopsies of lung, liver or kidney.

Clinicaltrials.gov

Open-Label Safety Study of AXS-05 in Subjects With Depression

An open-label, long-term, safety study of AXS-05 in patients with major depressive disorder (MDD), including treatment resistant depression.

Clinicaltrials.gov

Efficacy and Safety Outcomes of Optometrist Performed Selective Laser...

To measure the efficacy and safety outcomes of SLT performed by optometrists.

Clinicaltrials.gov

PAVES Benchmarking Pilot Study of Daily Disposable Contact Lenses

The study will compare the short-term clinical performance and wearer and practitioner acceptability in a pilot study of a new-to-market spherical silicone hydrogel daily disposable soft contact lens (SiHyDD)...

Clinicaltrials.gov

Mechanisms Of Change in Adolescent Pain Self-management

The MOCAS Study aims to describe the mechanisms through which sleep deficiency affects youth responses to an online pain self-management intervention over a 6-month period. The study is a single arm trial with...

Clinicaltrials.gov

Efficacy and Safety of Oral Rifaximin in Patients With Active...

This is an open label study looking at rifaximin therapy for the treatment of microscopic (collagenous or lymphocytic) colitis.