PCORI Integrated Care (IC) Models for Patient-Centered Outcomes

A new asthma drug candidate called fevipiprant

The overall purpose of this study is to determine the efficacy of fevipiprant (dose 1 and dose 2 once daily), compared with placebo, as add-on to standard-of-care asthma therapy, in terms of avoidance of...

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Evaluating Efficacy of Smart Device in Assisting With Inhaler...

Asthma affects over 10 million children in the U.S., and poses a significant health and cost burden. Metered dose inhaler (MDI) is the most common method of treatment. Studies show that up to 80% of patients...

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The Dallas Asthma Brain and Cognition (ABC) Study

Asthma is a chronic inflammatory airway disease that leads to episodic symptom exacerbations, which exerts a substantial burden on quality of life and can influence other health domains if not adequately...

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New Approaches for Empowering Studies of Asthma in Populations of...

Background: Some groups of people have a high prevalence of asthma and allergic disease. Also, asthma and allergic disease are often found in several members of the same family. Researchers want to learn more...

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Adapting and Expanding the Asthma-Educator App

This project seeks to test and refine an adapted/expanded version of a previously created ASTHMAXcel app.

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AdheRence to Inhaled Corticosteroids in Asthma

It is widely recognized that asthma in adult African American patients is a significant health problem, which is partly affected by relatively low inhaled corticosteroid (ICS) adherence rates. The goal of this...

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Continuation of TRAVERSE- LTS12551 Evaluating Dupilumab Safety in...

Primary Objective: To describe the long-term safety of dupilumab in treatment of patients with moderate to severe asthma who completed the previous asthma clinical trial (TRAVERSE-LTS12551).

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Vaginal Microbiome Exposure and Immune Responses in C-section Infants

The purpose of this research study is to assess at how differences in the microbiome (naturally occurring bacteria) of a baby may protect, or put a baby at risk, for allergic problems. The microbiome refers to...

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Peer-Administered Asthma Self-Management Intervention in Urban Middle...

Health disparities in pediatric asthma persist, with Latino children demonstrating increased asthma morbidity. Middle school children with asthma have greater morbidity than children from any other age group...

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Aligning With Schools To Help Manage Asthma (Project ASTHMA)

Project ASTHMA is a school-based health center intervention program that institutes guideline-based chronic asthma care and provides supervised administration with daily preventive asthma medications to...

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Registry for Asthma Characterization and Recruitment 2

There is a need for people to take part in research studies to learn more about diseases and how to treat them. The Registry for Asthma Characterization and Recruitment 2 (RACR2) will create a database of...

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Characterization of Adult Subjects for Asthmatic Research Studies

This study is designed to characterize subjects in terms of the nature and severity of their asthma and in terms of conditions that may alter the clinical expression of asthma. Some features will be obtained...

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Dexpramipexole Dose-Ranging Biomarker Study in Subjects With...

This is a randomized, double-blind, placebo-controlled, parallel-group, dose-ranging, multi-center study to evaluate the clinical effects of oral administration of dexpramipexole for 12 weeks on peripheral...

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The Tailored Adherence Incentives for Childhood Asthma Medications...

Improving adherence to inhaled corticosteroids (ICS) medication in urban minority pediatric populations is a clinical and population health priority. Financial incentives have been shown as a compelling method...

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Clinic Navigation and Home Visits to Improve Guideline-based Care and...

Asthma-related deaths are more numerous among low-income minority patients and older adults with chronic diseases. Guidelines for asthma management have not addressed the needs of these groups. The...

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Technology-Assisted Stepped Care Study

The overall goal of this project is to demonstrate the feasibility, implementation, and preliminary efficacy of a technology-assisted stepped care (TASC) adherence-promotion intervention in adolescents with...

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Technology- Assisted Stepped Care Intervention Study

The overall goal of this project is to demonstrate the feasibility, implementation, and preliminary efficacy of a technology-assisted stepped care (TASC) adherence-promotion intervention in adolescents with...

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Safety of LAIV4 in Children With Asthma

This is a prospective randomized, open label clinical trial in approximately 300 children aged 5-11 years with a physician diagnosis of persistent asthma. Participants will be randomized 1:1 to receive either...

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Translating an Efficacious Illness Management Intervention for Youth...

The propose of the study is to test the effectiveness of Reach for Control (RFC) as compared to Michigan MATCH to improve asthma symptoms, asthma management and lung functioning and to decrease ED visits and...

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A Trial of Mepolizumab Adjunctive Therapy for the Prevention of...

The purpose of this study is to see if treatment with a medication called Nucala® (mepolizumab), given along with standard asthma care, makes children less likely to have asthma attacks.

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Screening Inhaled Allergen Challenge for Dermatophagoides Farinae

This study is designed to identify Dermatophagoides farinae, or Der f, sensitive asthmatics who demonstrate a late phase asthmatic response after Der f inhalation. These subjects may be invited to participate...

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Patient Empowered Strategy to Reduce Asthma Morbidity in Highly...

Asthma imposes a significant burden in the US in terms of morbidity, costs to society, individual suffering, loss of productivity and mortality. African Americans (AA) and Hispanic/Latinos (H/L) bear a...

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Increased Lung Volume as Controller Therapy for Asthma

This is an early phase clinical trial to test the efficacy of elevating lung volume with positive expiratory pressure (CPAP) as a controller therapy for asthma in patients with a BMI ≥ 30 kg/m2. There will be...

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Sorting and Expression Profiling of Airway Cells From Humans (The...

This will be a single site, mechanistic study of asthmatic subjects and healthy, non-asthmatic controls involving a baseline characterization visit and a research bronchoscopy visit. We will identify...

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Trial of AccuPAP Device Versus Standard Nebulizer Therapy in Acute...

The objective of this randomized control trial is to investigate the efficacy of an adjunct positive airway pressure (PAP) nebulizer device known as "AccuPAP" in the treatment of moderate-severity acute asthma...

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Mechanisms of Exacerbation of Asthma

The purpose of this study is to identify the causes of asthma that were not previously suspected, to better understand the effects of inhaled steroids on asthma and to identify new way to treat asthma.

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Environmental Polymorphisms Registry

This study conducted by the NIEHS and the University of North Carolina Medical Center will create and maintain a biorespository containing the genetic material (DNA) from up to 20,000 individuals recruited...

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Genotype-tailored Treatment of Symptomatic Acid-Reflux in Children...

This study will evaluate the effect of CYP2C19 and ABCB1 genes on pharmacokinetics of lansoprazole in children with mild gastroesophageal reflux (GER) and uncontrolled asthma. It will determine if...

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Phosphodiesterase 4 Inhibitor, Roflumilast, and the Effects of...

This study evaluates the effects of roflumilast on restoring response β2 adrenoreceptor agonists in low T2, obese asthmatics. One group of participants will receive roflumilast for 3 months, while the other...

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Remote Physician Care for Home Hospital Patients

This study examines the implications of providing remote physician care to home hospitalized patients compared to usual home hospital care with in-person/in-home physician visits.

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Symptom Clusters in Children With Exacerbation-prone Asthma

Pediatric participants with exacerbation-prone asthma will receive an intramuscular injection of triamcinolone acetonide and will be followed for 48 weeks. The study visit 2 weeks after the injection will...

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Study in Adult Asthmatic Patients With Allergic Bronchopulmonary...

A Randomized, Double-Blind, Multicenter, Placebo-Controlled, Phase 2 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Itraconazole Administered as a Dry Powder for Inhalation (PUR1900) in...

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The Effect of NAC on Lung Function and CT Mucus Score

This study evaluates 20% n-acetylcysteine (NAC) in the treatment of moderate-to-severe asthma that is complicated by mucus in the airway, as determined by CT imaging. The study is a crossover design, which...

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Ginger's Therapeutic Potential in Asthma

This is a randomized, double blind, placebo controlled study to study whether there are potential benefits of consuming ginger by individuals with asthma.

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Peak Expiratory Flow Rate for Emergency Department Management of...

Patients presenting to the emergency department with acute asthma exacerbation will be assigned to peak-expiratory flow rate (PEFR) guided management and non-PEFR guided management.

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Characterization of Adults for Asthma Microbiome Research Studies

The purpose of this study is to characterize adult subjects regarding their history of allergy and asthma, clinical manifestations of asthma, and exposures and conditions that may influence asthma severity and...

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AIRWEIGHS: Investigating Obesity as a Susceptibility Factor for Air...

Background: Asthma and obesity are public health crises that have concurrently risen over the past decades, affecting millions of children in the United States and disproportionately affecting low-income...

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Preventing Asthma in High Risk Kids

This trial is a randomized, double-blind, placebo controlled trial designed to test whether two years treatment of preschool children aged 2-3 years of age at high risk for asthma with omalizumab (anti-IgE)...

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The Genetics of Severe Asthma in Children

Near fatal asthma exacerbations are one of the most common causes of critical illness in children, accounting for approximately ten thousand intensive care unit (ICU) admissions per year in the United States....

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Mechanism(s) of Airflow Limitation During Exacerbation of Asthma

The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory...

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Immune Interactions in Severe Asthma

This research study is being done to learn more about severe asthma by comparing people with severe asthma to those with milder forms of asthma and people without asthma, at baseline and over time. Individuals...

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A Study to Assess the Pharmacokinetics (PK), Pharmacodynamics (PD)...

This is an open-label, multi-centre, Phase I study to assess the PK, PD and safety of 2 week treatment with inhaled AZD7594 in adolescent patients with asthma. The study is planned to be conducted at 4-10...

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Asthma and Obesity: Pilot Study

Develop and pilot test four theory-based educational modules that integrate counseling for asthma and obesity to promote greater physical activity among people with asthma.

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An Asthma Mobile Intervention to Promote Patient-Reported Outcomes in...

Through this study, the investigators will adapt the ASTHMAXcel mobile app and evaluate the adapted intervention through a randomized controlled trial.

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Technology Enabled Asthma Management System (TEAMS) Pilot Study

To evaluate feasibility, acceptability, safety, and preliminary efficacy of a novel patient-centered, technology-based intervention to improve asthma care in younger adult smartphone users. The program, called...

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The Effect of Cetirizine on Bronchoconstriction

The purpose of this study is to determine the effect of cetirizine, an oral antihistamine, on wheezing in patients with allergic rhinitis. Patients presenting to the pediatric emergency department who have a...

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Pneumococcal Vaccines in Patients With Asthma

Investigators are assessing if patients with asthma respond better to the Pneumovax vaccine if they are given Prevnar initially.

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Treating Caregiver Depression to Improve Childhood Asthma: Impact and...

The investigators propose a one-year, repeated measures, within-subject design to examine the impact of improved caregiver depression on child asthma outcomes. A cross-lagged panel modeling (CLPM) for...

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Biomarkers of Irritant-Induced and Allergic Asthma

Asthma is a heterogeneous disease, and although much is understood about mechanisms of inflammation in allergic asthma, less is known about mechanisms of irritant-induced asthma (IA). Understanding the...

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Upper Airway Microbial Development During the First Year of Life

This study tests the hypothesis that an increase in pathogenic bacteria within the infant airway leads to increased airway inflammation, decreased airway function and ultimately airway obstruction throughout...

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Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma

The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory...