Adapting and Expanding the Asthma-Educator App

A new asthma drug candidate called fevipiprant

The overall purpose of this study is to determine the efficacy of fevipiprant (dose 1 and dose 2 once daily), compared with placebo, as add-on to standard-of-care asthma therapy, in terms of avoidance of...

Clinicaltrials.gov

Trial of Tauroursodeoxycholic Acid (TUDCA) in Asthma

Asthma is a chronic lung disease that affects millions of people worldwide, including both children and adults. The cause of asthma is not known, but asthma is strongly associated with inflammation of the...

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Inpatient Clinical Trial of NAC

The purpose of this study is to determine the beneficial effect of n-acetylcysteine (NAC), an inhaled medication that breaks down mucus, on lung function. NAC is a medication approved by the US Food and Drug...

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Clinical Endpoint Bioequivalence Study of Fluticasone Propionate &...

A Randomized, Parallel-Group, Placebo-Controlled, Clinical Endpoint Bioequivalence Study of Generic Fluticasone Propionate 100 μg and Salmeterol Xinafoate 50 μg Inhalation Powder Compared with Advair Diskus®...

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Peak Expiratory Flow Rate for Emergency Department Management of...

Patients presenting to the emergency department with acute asthma exacerbation will be assigned to peak-expiratory flow rate (PEFR) guided management and non-PEFR guided management.

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Ginger's Therapeutic Potential in Asthma

This is a randomized, double blind, placebo controlled study to study whether there are potential benefits of consuming ginger by individuals with asthma.

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Benralizumab in the Treatment of Eosinophilic Granulomatosis With...

Benralizumab is a type of medicine called a monoclonal antibody that is made in the research clinic; it works by blocking a specific protein in the body called interleukin-5. The study medicine, benralizumab,...

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Electronic Monitoring of Medication Adherence in Moderate to Severe...

This study will evaluate the role of using electronic sensors for asthma inhaler devices in monitoring medication adherence and asthma control

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AIRWEIGHS: Investigating Obesity as a Susceptibility Factor for Air...

Background: Asthma and obesity are public health crises that have concurrently risen over the past decades, affecting millions of children in the United States and disproportionately affecting low-income...

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Preventing Asthma in High Risk Kids

This trial is a randomized, double-blind, placebo controlled trial designed to test whether two years treatment of preschool children aged 2-3 years of age at high risk for asthma with omalizumab (anti-IgE)...

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Immune Interactions in Severe Asthma

This research study is being done to learn more about severe asthma by comparing people with severe asthma to those with milder forms of asthma and people without asthma, at baseline and over time. Individuals...

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Randomized, Placebo-controlled, Multi-dose, Study Comparing...

A randomized multiple-dose, placebo-controlled, parallel group design consisting of a 2-week run-in period followed by a 6-week treatment period of the placebo, Test product (Budesonide 80 mcg / Formoterol...

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Mechanism(s) of Airflow Limitation During Exacerbation of Asthma

The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory...

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The Genetics of Severe Asthma in Children

Near fatal asthma exacerbations are one of the most common causes of critical illness in children, accounting for approximately ten thousand intensive care unit (ICU) admissions per year in the United States....

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Inflammatory Mediators and microRNA Analysis in Premenstrual Asthma

A small number of women with asthma have an increase in asthma symptoms during the premenstrual or menstrual period. This study is being done to investigate the possible causes of this premenstrual increase in...

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Kids 2 Be & Breathe: A Study on the Use of Yoga and Mindfulness in...

This proposed pilot study will examine the tolerability, feasibility, acceptability, and preliminary effects of a gentle yoga intervention "Kids 2 Be & Breathe" (K2B2; a manualized 30 minute gentle yoga and...

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The Dallas Asthma Brain and Cognition (ABC) Study

Asthma is a chronic inflammatory airway disease that leads to episodic symptom exacerbations, which exerts a substantial burden on quality of life and can influence other health domains if not adequately...

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Incentives for Adherence in Adolescent Asthma

Financial incentives have been suggested as a possible means for increasing adherence to asthma medications. This study will evaluate an incentive strategy (daily small reward for adherence) in maintaining...

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Aligning With Schools To Help Manage Asthma (Project ASTHMA)

Project ASTHMA is a school-based health center intervention program that institutes guideline-based chronic asthma care and provides supervised administration with daily preventive asthma medications to...

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Reslizumab in the Treatment of Eosinophilic Granulomatosis With...

Reslizumab is a type of medicine called a monoclonal antibody that is made in the research clinic; it works by blocking a specific protein in the body called interleukin-5. The study medicine, reslizumab, is...

Clinicaltrials.gov

Association of Transcutaneous Pulse CO-oximetry With Inflammatory...

This is a pilot cross-sectional study of measured transcutaneous CO-oximetry in children with inflammatory and non-inflammatory conditions.

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Registry for Asthma Characterization and Recruitment 2

There is a need for people to take part in research studies to learn more about diseases and how to treat them. The Registry for Asthma Characterization and Recruitment 2 (RACR2) will create a database of...

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The Effects of NOx and Conjugated Linoleic Acid on Asthmatics

This study will examine the hypothesis that in obese asthmatics; treatment with NOx + CLA is well tolerated, safe and will increase eNO while reducing airway oxidative stress. Allied with this, the...

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Characterization of Adult Subjects for Asthmatic Research Studies

This study is designed to characterize subjects in terms of the nature and severity of their asthma and in terms of conditions that may alter the clinical expression of asthma. Some features will be obtained...

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Vaginal Microbiome Exposure and Immune Responses in C-section Infants

The purpose of this research study is to assess at how differences in the microbiome (naturally occurring bacteria) of a baby may protect, or put a baby at risk, for allergic problems. The microbiome refers to...

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Peer-Administered Asthma Self-Management Intervention in Urban Middle...

Health disparities in pediatric asthma persist, with Latino children demonstrating increased asthma morbidity. Middle school children with asthma have greater morbidity than children from any other age group...

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Continuation of TRAVERSE- LTS12551 Evaluating Dupilumab Safety in...

Primary Objective: To describe the long-term safety of dupilumab in treatment of patients with moderate to severe asthma who completed the previous asthma clinical trial (TRAVERSE-LTS12551).

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Technology Enabled Asthma Management System (TEAMS) Pilot Study

To evaluate feasibility, acceptability, safety, and preliminary efficacy of a novel patient-centered, technology-based intervention to improve asthma care in younger adult smartphone users. The program, called...

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Pediatric ASTHMA-Educator

This project seeks to develop and pilot test the pediatric ASTHMA-Educator mobile application.

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Observational Study of Characteristics, Treatment and Outcomes With...

The CHRONICLE Study is a multi-center, non-interventional, prospective cohort study of adults with severe asthma who do not achieve control with high-dose inhaled corticosteroid (ICS) therapy with additional...

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BE Study of Fluticasone Propionate/Salmeterol Inhalation Powder in...

The purpose of this study is to demonstrate the pharmacodynamic bioequivalence of the test product to the reference product in adult patients with asthma.

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Pneumococcal Vaccines in Patients With Asthma

Investigators are assessing if patients with asthma respond better to the Pneumovax vaccine if they are given Prevnar initially.

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Biomarkers of Irritant-Induced and Allergic Asthma

Asthma is a heterogeneous disease, and although much is understood about mechanisms of inflammation in allergic asthma, less is known about mechanisms of irritant-induced asthma (IA). Understanding the...

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Airway Temperature

Airway irritation, cough and bronchial spasm are common symptoms in patients with airway inflammatory diseases such as asthma. The primary focus of this exploratory study is to determine if there is an...

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Indoor Air Pollution and Children With Asthma: An Intervention Trial

The purpose of this study is to determine whether reducing indoor exposure to NO2 and particles improves respiratory health in children with asthma.

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Upper Airway Microbial Development During the First Year of Life

This study tests the hypothesis that an increase in pathogenic bacteria within the infant airway leads to increased airway inflammation, decreased airway function and ultimately airway obstruction throughout...

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Longitudinal Observational Study of Severe Asthma

Background: - Asthma is a lung condition that causes difficulty breathing and decreased lung function. Some people with asthma have more severe disease symptoms. They may be less responsive to standard...

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TGF-(Beta) and Susceptibility to RSV

Background: - Human respiratory syncytial virus (RSV) is a virus that causes respiratory tract infections, and is frequently responsible for hospital visits in infants and children. It can also trigger severe...

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A Study to Assess the Efficacy and Safety of Multiple Dose Levels of...

This study will assess the efficacy and safety of multiple dose levels of AZD7594 administered once daily (QD) by inhalation in a 12-week treatment period on asthma subjects. The activity will be assessed by...

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Pilot of Lifestyle and Asthma Intervention

This is to pilot test a weight loss intervention in obese patients with poorly controlled asthma. Obesity is a risk factor for the development of asthma (approximately 250,000 cases per year of asthma in the...

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Assessment of the Safety and Efficacy of Dupilumab in Children With...

Primary Objective: To evaluate the long-term safety and tolerability of dupilumab in pediatric patients with asthma who participated in a previous dupilumab asthma clinical study. Secondary Objectives: - To...

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Feasibility and Acceptability of the Hailie Monitoring System in...

The main hypothesis of this study is to see if children and adolescents with poorly controlled asthma will find the Hailie Smart Inhaler electronic monitoring device is feasible and acceptable, and will result...

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Study to Evaluate Efficacy and Safety of Benralizumab in Reducing...

This is a study designed to evaluate efficacy and safety of Benralizumab in reducing the Oral Corticosteroid (OCS) use in adult patients with severe asthma who are receiving OCS with or without additional...

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Study to Evaluate Tezepelumab in Adults & Adolescents With Severe...

A Multicentre, Randomized, Double-Blind, Placebo Controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Tezepelumab in Adults and Adolescents with Severe Uncontrolled Asthma

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RVA Breathes: A Richmond City Collaboration to Reduce Pediatric...

The goal of this study is to evaluate a sustainable, community-engaged program to reduce asthma disparities among 5 to 11-year-old children in Richmond, Virginia. Richmond, an urban center, has been named the...

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Detroit Young Adult Asthma Project

The purpose of the Detroit Young Adult Asthma Project is to test a technology based program to help African American young adults learn to better manage their asthma. Participants will be randomized to a...

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Cysteamine for Asthma

The purpose of this study is to see if a medicine called Cysteamine, given along with standard asthma care, will improve asthma symptoms and lung function.

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The Study is Enrolling Kids From 7 to 16 Years Old. The BreathSmart...

Non-adherence to controller medication is a common problem in children with Asthma, resulting in overuse of reliever medication, increased asthma symptoms, more frequent Asthma attacks, and increased emergency...

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Trial of Roflumilast in Asthma Management (TRIM)

There are currently no treatments to specifically target asthma in obese adults. This pilot study is being conducted to investigate how effective roflumilast is in treating asthma in participants that have a...

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A Study of Gamma Tocopherol-enriched Supplement on Lower Airway...

Purpose: To determine the efficacy of 1400 mg gamma tocopherol-enriched supplement for mitigating inhaled wood smoke particle-induced airway inflammation in healthy adults with no more than mild asthma.

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Allogeneic Human Cells (hMSC) Via Intravenous Delivery in Patients...

A Phase 1 investigation will be performed to test the safety of two doses of bone marrow-derived MSCs (20,000,000 and 100,000,000) administered via peripheral intravenous infusion.