FDG PET-MRI for the Diagnosis of Spinal Cord Lesions

Clinical Trial ID: NCT04219969

Description

This trial studies the best time point of using F18-FDG that gives the best image on PET-MRI in patients with spinal cord lesions of unknown cause. Diagnostic procedures, such as F18-FDG PET-MRI, may help find and diagnose spinal cord lesions.

PRIMARY OBJECTIVES: I. To identify the optimal imaging time point using fludeoxyglucose F-18 (F18-FDG) positron emission tomography (PET) that gives the best lesion conspicuity as defined by the best lesion to background (L/B) ratio when evaluating spinal cord lesions of unknown etiology. EXPLORATORY OBJECTIVES: I. To identify malignancy specific factors in F18-FDG metabolism derived from metrics such as maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), total lesion glycolysis (TLG), metabolic tumor volume (MTV) and L/B ratio. OUTLINE: Patients receive fludeoxyglucose F-18 intravenously (IV) over 1 minutes and then undergo PET-magnetic resonance imaging (MRI) over 15-60 minutes at 60, 300, and 480 minutes after fludeoxyglucose F-18 injection in the absence of unacceptable toxicity.


Criteria

Inclusion Criteria: - Patients with untreated intramedullary cord lesion(s) - Ability to undergo FDG PET MR examination Exclusion Criteria: - No prior surgery or biopsy of the spinal cord - No metal implanted in area of interest - Spine radiation therapy - Known allergy to FDG or gadolinium based contrast agents - Blood glucose (> 200 mg/dl) - Pregnant women are excluded - Need for conscious sedation or anesthesia in order to tolerate study

  • Start Date

    2018-09-21

  • Last Updated

    2020-01-04

  • Sponsor

    National Cancer Institute (NCI)

  • Condition Name

    Spinal Cord Neoplasm

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